133512-64-8

Basic information

• Product Name: 1-(4-(perfluoroethyl)phenyl)ethan-1-one
• Synonyms: 1-(4-(perfluoroethyl)phenyl)ethan-1-one
• CAS NO: 133512-64-8
• Molecular Weight: 238.157
• Mol File: 133512-64-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-(4-(perfluoroethyl)phenyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(perfluoroethyl)phenyl)ethan-1-one(133512-64-8)
• EPA Substance Registry System: 1-(4-(perfluoroethyl)phenyl)ethan-1-one(133512-64-8)

Safety Data

• Hazardous Substances Data: 133512-64-8(Hazardous Substances Data)

Upstream product

• 99-92-3 p-aminobenzophenone 
• 60007-39-8 pentafluoroethylcopper(I) 
• 350-47-0 1-(4-acetylphenyl)diazonium tetrafluoroborate 
• 149104-90-5 4-acetylphenylboronic acid 
• 13329-40-3 4-Iodoacetophenone 
• 124898-13-1 trimethyl(pentafluoroethyl)silane 

Relevant articles and documents

Pentafluoroethylation of Arenediazonium Tetrafluoroborates Using On-Site Generated Tetrafluoroethylene

Copper-mediated pentafluoroethylation of arenediazonium tetrafluoroborates with tetrafluoroethylene (TFE) on-site generated from TMSCF3 has been developed as a new method to prepare pentafluoroethyl arenes. The active pentafluoroethylation reagent “CuC2F5” is pre-generated from CuSCN, TFE and CsF, and its generation and further reaction are strongly solvent-dependent. This pentafluoroethylation reaction represents the first example of Sandmeyer-type pentafluoroethylation, which exhibits good functional group tolerance and potential applications for the synthesis of complicated bioactive compounds.

A class of effective decarboxylative perfluoroalkylating reagents: [(phen)2Cu](O2CRF)

This article describes the invention of a class of effective reagents [(phen)2Cu](O2CRF) (1) for the decarboxylative perfluoroalkylation of aryl and heteroaryl halides. Treatment of copper tert-butyloxide with phenanthroline ligands, with subsequent addition of perfluorocarboxylic acids afforded air-stable copper(i) perfluorocarboxylato complexes 1. These complexes reacted with a variety of aryl and heteroaryl halides to form perfluoroalkyl(hetero)arenes in moderate to high yields. Computational studies suggested that the coordination of the second phen ligand may reduce the energy barrier for the decarboxylation of perfluorocarboxylate to facilitate perfluoroalkylation.

Pentafluoroethylating compositions

The present invention relates to pentafluoroethylating compositions, processes for obtaining them, and their use in pentafluoroethylation reactions.