1335139-75-7

Upstream product

• 83948-53-2 3-bromopropylamine tert-butylcarbamate 
• 1335144-15-4 methyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate 
• 1335139-10-0 [1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methanol 
• 1335139-09-7 ethyl 1-(trans-4-methylcyclohexyl)-1H-imidazole-4-carboxylate 
• 2523-55-9 trans-4-methylcyclohexanamine 
• 1335139-08-6 1-(trans-4-methylcyclohexyl)-1H-imidazole-4-carbaldehyde 
• 1335139-06-4 5-[(tert-butoxycarbonyl)amino]-2-(methoxycarbonyl)valeric acid 
• 1335139-07-5 dimethyl 2-(3-((tert-butoxycarbonyl)amino)propyl)malonate 
• 1335144-16-5 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1335138-63-0 benzyl 5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate hydrochloride 
• 1335139-76-8 benzyl 5-({N-[(benzyloxy)carbonyl]-L-phenylalanyl}amino)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate 
• 1335138-64-1 2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}-5-(L-phenylalanylamino)valeric acid 

Relevant academic research and scientific papers

CYCLOALKYL-SUBSTITUTED IMIDAZOLE DERIVATIVE

A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof, wherein A represents a C3 to C12 cycloalkyl group which may be substituted by one to three selected from a fluoro group, a hydroxy group, a C1 to C6 alkyl group, etc; R1, R2, and R3 each independently represent a hydrogen atom, a fluoro group, or a C1 to C6 alkyl group; R4 represents a hydrogen atom or a prodrug group; and Y represents -CH2-CHR5-CH2-NHR6 (wherein R5 represents a hydrogen atom, a C1 to C6 alkyl group, or a C1 to C6 alkoxy group, and R6 represents a hydrogen atom or a prodrug group), or the like exhibits excellent TAFIa inhibitory activity and is useful as a therapeutic drug for myocardial infarction, angina pectoris, acute coronary syndrome, cerebral infarction, deep vein thrombosis, pulmonary embolism, and the like.