benzyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

Base Information

Chemical Name:benzyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate
CAS No.:1335139-75-7
Molecular Formula:C₂₈H₄₁N₃O₄
Molecular Weight:483.651
Hs Code.:

Synonyms:benzyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

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Chemical Property of benzyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

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Technology Process of benzyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

There total 10 articles about benzyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1335144-16-5
5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

: 100-51-6,185532-71-2
benzyl alcohol

: 1335139-75-7
benzyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 1335139-07-5
dimethyl 2-(3-((tert-butoxycarbonyl)amino)propyl)malonate

: 1335139-75-7
benzyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hydroxide monohydrate / methanol; water / 15 h / 0 - 20 °C

2: piperidine; propionic acid / cyclohexane / 48 h / Reflux

3: palladium 10% on activated carbon; hydrogen; water / ethanol / 6.5 h / 20 - 60 °C / 760.05 Torr

4: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 18 h / 20 °C

With piperidine; dmap; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; propionic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; cyclohexane; water; 2: |Knoevenagel Condensation;

Reference yield:

: 1335139-08-6
1-(trans-4-methylcyclohexyl)-1H-imidazole-4-carbaldehyde

: 1335139-75-7
benzyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine; propionic acid / cyclohexane / 48 h / Reflux

2: palladium 10% on activated carbon; hydrogen; water / ethanol / 6.5 h / 20 - 60 °C / 760.05 Torr

3: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 18 h / 20 °C

With piperidine; dmap; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; propionic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; dichloromethane; cyclohexane; water; 1: |Knoevenagel Condensation;