133524-23-9

Basic information

• Product Name: tert-butyl 4-benzoylbenzoate
• Synonyms: tert-butyl 4-benzoylbenzoate
• CAS NO: 133524-23-9
• Molecular Weight: 282.339
• Mol File: 133524-23-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-benzoylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-benzoylbenzoate(133524-23-9)
• EPA Substance Registry System: tert-butyl 4-benzoylbenzoate(133524-23-9)

Safety Data

• Hazardous Substances Data: 133524-23-9(Hazardous Substances Data)

Upstream product

• 611-95-0 4-carboxybenzophenone 
• 75-65-0 tert-butyl alcohol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 108-86-1 bromobenzene 
• 65874-27-3 4-(tert-butoxycarbonyl)benzaldehyde 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 120363-13-5 tert-butyl 4-iodobenzoate 
• 135364-97-5 tert-butyl benzoyl(tert-butoxycarbonyl)carbamate 

Relevant articles and documents

Synthesis of biaryl ketones by arylation of Weinreb amides with functionalized Grignard reagents under thermodynamic controlvs.kinetic control ofN,N-Boc2-amides

A highly efficient method for chemoselective synthesis of biaryl ketones by arylation of Weinreb amides (N-methoxy-N-methylamides) with functionalized Grignard reagents is reported. This protocol offers rapid entry to functionalized biaryl ketones after Mg/halide exchange with i-PrMgCl·LiCl under operationally-simple and practical reaction conditions. The scope of the method is highlighted in >40 examples, including bioactive compounds and pharmaceutical derivatives. Collectively, this transition-metal-free approach offers a major advantage over the recently established cross-coupling of amides by oxidative addition of N-C(O) bonds. Considering the utility of amide acylation reactions in modern synthesis, we expect that this method will be of broad interest.

Palladium-catalyzed synthesis of diaryl ketones from aldehydes and (hetero)aryl halides via C-H bond activation

We developed a palladium-catalyzed C-H transformation that enabled the synthesis of ketones from aldehydes and (hetero)aryl halides. The use of picolinamide ligands was key to achieving the transformation. Heteroaryl ketones, as well as diaryl ketones, were synthesized in good to excellent yields, even in gram-scale, using this reaction. Results of density functional theory (DFT) calculations support the C-H bond activation pathway.

MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF

Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein