1335387-26-2

Basic information

• Product Name: C₂₅H₃₄IN₃O₇S
• CAS NO: 1335387-26-2
• Molecular Weight: 647.531
• Mol File: 1335387-26-2.mol

Chemical Properties

• CAS DataBase Reference: C₂₅H₃₄IN₃O₇S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₃₄IN₃O₇S(1335387-26-2)
• EPA Substance Registry System: C₂₅H₃₄IN₃O₇S(1335387-26-2)

Safety Data

• Hazardous Substances Data: 1335387-26-2(Hazardous Substances Data)

Upstream product

• 113850-76-3 N-(tert-butoxycarbonyl)-4-iodo-L-phenylalanine methyl ester 
• 1991-81-7 4-iodo-L-phenylalanine 
• 63-91-2 L-phenylalanine 
• 1335387-24-0 C₁₉H₃₁IN₂O₃ 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 1335387-17-1 C₁₅H₁₉ClINO₃ 

Downstream Products

• 1335387-05-7 (S)-tetrahydrofuran-3-yl ((2S,3R)-1-([1,1'-biphenyl]-4-yl)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxybutan-2-yl)carbamate 
• 1335387-01-3 (S)-tetrahydrofuran-3-yl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-(4-(pyridin-3-yl)phenyl)butan-2-yl)carbamate 
• 1335387-04-6 (S)-tetrahydrofuran-3-yl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-(4-(pyridin-4-yl)phenyl)butan-2-yl)carbamate 
• 1335387-30-8 C₂₅H₃₂IN₃O₈S 
• 1365171-47-6 C₃₁H₃₇N₃O₈S 
• 1365171-48-7 C₃₀H₃₆N₄O₈S 
• 1365171-49-8 C₃₀H₃₆N₄O₈S 

Relevant articles and documents

Synthesis and biological evaluation of novel amprenavir-based P1-substituted bi-aryl derivatives as ultra-potent HIV-1 protease inhibitors

A series of P1-substituted biaryl amprenavir derivatives was designed and synthesized. These compounds were evaluated for enzyme inhibition and antiviral activity in vitro. Several compounds showed highly efficient antiviral activity with EC50 values down to 0.10 nM, which are more potent than marketed HIV-1 protease inhibitors. Docking study indicated that 12c has similar binding mode to amprenavir with full occupancy in P1.