133589-48-7

Upstream product

• 133589-49-8 (3aS,4R,7aR)-3,3a-Bis-benzyloxy-6-benzyloxymethyl-7-oxo-3a,4,7,7a-tetrahydro-benzofuran-4-carboxylic acid methyl ester 
• 186581-53-3 diazomethane 
• 133589-47-6 3a,4,7,7a-tetrahydro-8--3,3a-dibenzyloxy-4,7-etheno-5H-furo<2,3-c>pyran-5-one 
• 100-39-0 benzyl bromide 
• 116287-78-6 (1R,2S,6S,7S)-5,6-Bis-benzyloxy-10-hydroxymethyl-3,9-dioxa-tricyclo[5.2.2.0^2,6]undeca-4,10-dien-8-one 
• 133589-48-7 methyl 3a,4,7,7a-tetrahydro-7-hydroxy-6-benzyloxymethyl-3,3a-dibenzyloxybenzofuran-4-carboxylate 

Downstream Products

• 133589-52-3 methyl 2,3,3a,6,7,7a-hexahydro-7-hydroxy-6-hydroxymethyl-3-oxo-3a-benzyloxybenzofuran-4-carboxylate 
• 133589-51-2 methyl 2,3,3a,6,7,7a-hexahydro-7-hydroxy-3-oxo-3a-benzyloxy-6-benzyloxymethylbenzofuran-4-carboxylate 
• 133589-49-8 (3aS,4R,7aR)-3,3a-Bis-benzyloxy-6-benzyloxymethyl-7-oxo-3a,4,7,7a-tetrahydro-benzofuran-4-carboxylic acid methyl ester 
• 133589-48-7 methyl 3a,4,7,7a-tetrahydro-7-hydroxy-6-benzyloxymethyl-3,3a-dibenzyloxybenzofuran-4-carboxylate 

Relevant academic research and scientific papers

Synthesis of fully functionalized intermediates for the bottom half of the 4-acetoxymethyl milbemycin antibiotics (1)

Three fully functionalized bottom half synthons for the preparation of the 4-acyloxymethyl milbemycin antibiotics, e.g., milbemycins α9, α10, and F have been synthesized in only seven steps and reasonable overall yield by an application of our general app