133603-87-9

Upstream product

• 60434-95-9 (1E,1'E)-N,N'-(ethane-1,2-diyl)bis(1-(4-chlorophenyl)methanimine) 
• 60434-95-9 N,N'-bis(4-chlorobenzylidene)ethane-1,2-diamine 

Relevant academic research and scientific papers

A simple method of synthesis of (±)-2,3-diarylpiperazines and a novel method of resolution of (±)-2,3-diphenylpiperazine

Intramolecular reductive coupling of diimines in the presence of Zn/Ti(OiPr)2Cl2 gives the corresponding (±)-2,3-diarylpiperazines in 73-83% yields with dl/meso ratio >99%: 1%. The (±)-2,3-diphenylpiperazine obtained in t

Synthesis of chiral 2,3-disubstituted 1,4-diazabicyclo[2.2.2]octane derivatives

Racemic 2,3-diaryl-1,4-diazabicyclo[2.2.2]octane (DABCO) derivatives are synthesized from the readily accessible piperazines in 50-64% yield by cyclization using ethylene bromide, triethylamine, and KI at 80 °C. The enantiomerically enriched 2,3-diphenylpiperazine and the 2,3-bis(1-naphthyl)piperazine derivatives are prepared by a resolution method using commercially available optically active acids, yielding the corresponding DABCO derivatives in 51-64% yield with up to 99% ee. This mild cyclization can also be applied to enantiopure camphanyldiamine derivatives, and the products are obtained in 72-86% yields.

Diastereoselective synthesis of piperazines by manganese-mediated reductive cyclization.

A simple and effective synthesis of trans aryl-substituted piperazines using a Bronsted acid and manganese(0) is described. [reaction: see text]

Electroorganic Chemistry. 129. Electroreductive Synthesis of Chiral Piperazines and Enantioselective Addition of Diethylzinc to Aldehydes in the Presence of the Chiral Piperazines

Electroreduction of diimines, prepared from 1,2-diamines and aromatic aldehydes, in acidic media gave intramolecularly coupled products, 2,3-diarylpiperazines, stereoselectively.Chiral tri- and tetrasubstituted piperazines were synthesized effectively fro