60434-95-9

Usage

InChI:InChI=1/C16H14Cl2N2/c17-15-5-1-13(2-6-15)11-19-9-10-20-12-14-3-7-16(18)8-4-14/h1-8,11-12H,9-10H2/b19-11+,20-12+

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 107-15-3 ethylenediamine 
• 109-58-0 N-β-aminoethylcarbamic acid 
• 24692-44-2 3,4-dihydro-1,2,5-thiadiazole 

Downstream Products

• 58015-08-0 1,2-bis(p-chlorobenzylamino)ethane 
• 53654-70-9 N-(4-chloro-benzyl)-ethylenediamine 
• 81512-16-5 3,3'-(ethane-1,2-diyl)bis(2-(4-chlorophenyl)thiazolidin-4-one) 
• 5443-27-6 2-[1,3-bis-(4-chloro-benzyl)-imidazolidin-2-yl]-phenol 
• 1228115-66-9 Re(CO)3Cl(N,N'-(4-chlorobenzaldehyde)-1,2-diiminoethane) 
• 133603-87-9 trans-2,3-bis(4-chlorophenyl)piperazine 
• 1327208-39-8 1,1'-(ethane-1,2-diyl)bis(3-chloro-4-(4-chlorophenyl)azetidin-2-one) 
• 108897-53-6 N,N'-bis-(4-chloro-benzyl)-ethylenediamine; dihydrochloride 
• 115291-54-8 1,3-bis-(4-chloro-benzyl)-2-(2,3-dimethoxy-phenyl)-imidazolidine 
• 125644-07-7 4-[1,3-bis-(4-chloro-benzyl)-imidazolidin-2-yl]-2-methoxy-phenol 
• 115291-52-6 1,3-bis-(4-chloro-benzyl)-2-(2-methoxy-phenyl)-imidazolidine 
• 5428-35-3 1,3-di-(4-chlorobenzyl)-2-(4-metoxyphenyl)imidazolidine 
• 115143-45-8 4-[1,3-bis-(4-chloro-benzyl)-imidazolidin-2-yl]-phenol 
• 114277-04-2 1,3-bis-(4-chloro-benzyl)-2-p-tolyl-imidazolidine 

Relevant academic research and scientific papers

Synthesis and structural characterization of (2E,3E)-N1,N 2-Bis(4-chlorobenzylidene)ethane-1,2-diamine

Present compound (2E,3E)-N1,N2-bis(4- chlorobenzylidene)ethane-1,2-diamine (C16H14C 14N2, Mr = 305.19) was synthesized and characterized by elemental analysis, FT-IR, 1H NMR and single crystal X-ray diffraction. The crystal belongs to monoclinic, space group Cc, with a = 10.166(2), b = 10.345(2), c = 26.650(5) ?, β = 91.91(3)°, V = 2801.1(10) ?3, Z = 8, Dc = 1.447 g/cm3, λ = 0.71073 ?, μ(MoKα) = 0.454 mm-1, F (000) = 1264. The final refinement gave R = 0.0652, wR(F2) = 0.1582 for 4,578 observed reflections with I > 2σ (I). X-Ray diffraction analysis reveals that the asymmetric unit of the title compound consists of two independent molecules. Each independent molecule adopts an E configuration about the central C=N functional bond. The dihedral angles between the two benzene rings are 2.3(2) and 0.5(2)°, respectively in two independent molecules. The molecules are linked through C- H···Cl hydrogen bonds interactions.

Modification of platinum nanoparticles loaded on activated carbon and activated carbon with a new chelating agent for solid phase extraction of some metal ions

The present study as simple and efficient is based on application of platinum nanoparticle loaded on activated carbon (Pt-NP-AC) which characterized by SEM, TEM and XRD. Pt-NP-AC and activated carbon (AC) that efficiently modified by impregnation of new c

Phototriggered cytotoxic properties of tricarbonyl manganese(I) complexes bearing α-diimine ligands towards HepG2

Reaction between bromo tricarbonyl manganese(I) and N,N′-bis(phenyl)-1,4-diaza-1,3-butadiene ligands, bearing different electron-donating and electron-withdrawing groups R?=?OCH3, Cl, and NO2 in the ortho- and para-positions on the p

Design and application of diimine-based copper(i) complexes in photoredox catalysis

Structurally different bis(imino)copper(i) complexes were prepared in a highly modular manner and utilized as copper-based photocatalysts in the ATRA reactions of styrenes and alkyl halides. The new photocatalysts showed good catalytic activity and ensured efficient chemical transformations.

Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1

The rise in multidrug resistant (MDR) cases of tuberculosis (TB) has led to the need for the development of TB drugs with different mechanisms of action. The genome sequence of Mycobacterium tuberculosis (Mtb) revealed twenty different genes coding for cy

Facile access to polymer supported zinc–salen complex: highly efficient heterogeneous catalyst for synthesizing hydantoins, thiohydantoins and Schiff bases in aqueous medium

The synthesis of polymer supported zinc–salen complex (PS-Zn–salen) is described. The mononuclear zinc(II)–salen complex was characterized by Fourier-transform NMR spectroscopy, energy-dispersive X-ray spectroscopy, Fourier transform infrared spectrophotometry (FT-IR), thermogravimetric analysis, scanning electron microscopy, surface area and pore size distribution by Brunauer–Emmett–Teller. The synthesized PS-Zn–salen complex used as a recyclable heterogeneous catalyst for the efficient synthesis of hydantoins, thiohydantoins and Schiff bases in an aqueous medium. The isolated yields of hydantoins, thiohydantoins and Schiff bases achieved up to 89, 95 and 94%, respectively. In spite of conventional heterogeneous catalysts, current PS-Zn–salen complex shows thermal stability up to 280?°C. Moreover, the catalyst could be recovered easily by simple filtration and reused for next run with slightly declining its activity up to six successive runs. The FT-IR spectrum of recycle catalyst after 6th run confirmed that the catalyst was stable during the course of a reaction. The leaching of metal from the PS-Zn–salen is negligible, which was confirmed by AAS and hot filtration test.

Nano tetraimine Pd(0) complex as an efficient catalyst for phosphine-free Suzuki reaction in water and copper-free Sonogashira reaction under aerobic conditions

A nano tetraimine Pd(0) complex catalyst was successfully used as an efficient heterogeneous catalyst for the phosphine-free palladium-catalysed Suzuki coupling reaction in water at 80 °C. This nano tetraimine Pd(0) complex was also used for copper-free Sonogashira reaction in dimethylformamide at 100 °C. The catalyst was easily recovered from the reaction mixture by centrifugation and reused for at least six cycles without any significant loss in its catalytic activity. Analysis of the reaction mixture using inductively coupled plasma analysis showed that leaching of palladium from the catalyst was negligible. The reactions can be performed efficiently for aryl iodides, bromides and also chlorides.

A nano tetraimine Pd(0) complex: Synthesis, characterization, computational studies and catalytic applications in the Heck-Mizoroki reaction in water

A new nano tetraimine Pd(0) complex was successfully prepared by the complexation of palladium acetate with an N,N-bisimine ligand. The structural features of the catalyst and the ligand were characterized using different microscopic and spectroscopic techniques such as FT-IR, XRD, XPS, UV-Vis, NMR, and elemental analysis. The morphology of the catalyst was determined using FE-SEM and TEM. The catalyst was effectively employed in the palladium-catalyzed Heck-Mizoroki reaction in water as a green solvent. The catalyst was reusable and recycled six times without any decrease in its catalytic activity. The ICP analysis showed that the catalyst has very little Pd leaching (0.2%) during the reaction process, demonstrating that our catalyst is stable and heterogeneous in practice. Furthermore, we have theoretically explored the feasibility of two neutral and cationic pathways in the density functional theory framework. The geometries and energies of all species involved in the reaction mechanism are analyzed.

A new family of doubly cyclopalladated diimines. A remarkable effect of the linker between the metalated units on their cytotoxicity

The cyclopalladation of a series of symmetric diimines with the formula (RC6H4CH=NZ)2, where Z = CH2 or (CH2)2OCH2 and R = p-Cl, p-OMe, p-NO 2, and o-Cl, is described. Optimal conditions to obtain the dimetalated compounds were found to be palladium(II) acetate, in toluene, at 60 °C and with a reaction time of 2-4 h. The reactivity of the dimetalated compounds with monodentate, bidentate, and bis(monodentate) Lewis bases was also studied. The cytotoxic activity of some selected compounds was evaluated against a panel of adenocarcinoma cell lines (colon HCT116 and breast MCF7 and MDA-MB231). Compounds containing the fragment NCH2CH 2OCH2CH2OCH2CH2N exhibited a remarkable cytotoxic activity in the three cancer cells assayed, but complexes containing the NCH2CH2N fragment showed no activity. It seems that the length and flexibility of the central saturated chain in the imine molecule, as well as its lipophilicity and hydrophilicity, explain the different cytotoxicity of the two series of coordination compounds here reported.

Synthesis, ir and nmr spectral correlations in some symmetrical diimines

A series of diimines have been synthesized by coupling of diamine with substituted benzaldehydes. The purities of these diimines were checked by their analytical and spectroscopic data. The spectral frequencies vCN (cm-1), NMR chemical shifts (v, ppm) of C-H and C=N of these diimines have been correlated with Hammett substituent constants, F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effect of substituents on the above spectral data has been studied.