133627-46-0 Usage
Description
2-Chloro-N-(2-chloro-4-methylpyridin-3-yl)nicotinamide is an organic compound that serves as an intermediate in the synthesis of Nivirapine, an antiretroviral medication used to treat HIV-1 infection. It is characterized by its pale yellow solid appearance.
Uses
Used in Pharmaceutical Industry:
2-Chloro-N-(2-chloro-4-methylpyridin-3-yl)nicotinamide is used as a chemical intermediate for the synthesis of Nivirapine, an antiretroviral drug. Its role in the pharmaceutical industry is crucial for the production of medications that help combat HIV-1 infection and improve the quality of life for patients living with the disease.
Check Digit Verification of cas no
The CAS Registry Mumber 133627-46-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,6,2 and 7 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 133627-46:
(8*1)+(7*3)+(6*3)+(5*6)+(4*2)+(3*7)+(2*4)+(1*6)=120
120 % 10 = 0
So 133627-46-0 is a valid CAS Registry Number.
InChI:InChI=1/C12H9Cl2N3O/c1-7-4-6-16-11(14)9(7)17-12(18)8-3-2-5-15-10(8)13/h2-6H,1H3,(H,17,18)
133627-46-0Relevant articles and documents
Efficient synthesis of nevirapine analogs to study its metabolic profile by click fishing
Bernard, Sylvain,Defoy, Daniel,Dory, Yves L.,Klarskov, Klaus
supporting information; experimental part, p. 6127 - 6130 (2010/06/13)
Knowledge of the biotransformation and pharmacokinetics of the antiretroviral agent nevirapine is still insufficient. In order to trace rash inducing metabolites of nevirapine, we devised a short and efficient multi-gram synthesis of a nevirapine analog that can be coupled to azide containing compounds by click chemistry.
AN IMPROVED PROCESS FOR INDUSTRIAL MANUFACTURE OF NEVIRAPINE
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Page/Page column 18, (2008/06/13)
An improved cost-effective, environmental friendly, industrial method for manufacture of Nevirapine.Formula (I):
Structural elucidation of an oxazolo[5,4-b]pyridine: An alternative cyclization product related to nevirapine
Norman,Minick,Martin
, p. 771 - 779 (2007/10/02)
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