133674-39-2

Upstream product

• 637-91-2 2,2-dimethylpropionaldehyde oxime 
• 134938-40-2 carbomethoxy(phenyl{[(trifluoromethyl)sulfonyl]oxy}iodo)acetylene 
• 630-19-3 pivalaldehyde 
• 922-67-8 propynoic acid methyl ester 
• 554-12-1 propanoic acid methyl ester 

Downstream Products

• 133674-40-5 3-tert-butylisoxazole-5-carboxylic acid 
• 1196104-05-8 3-tert-butyl-isoxazole-5-carbonyl chloride 
• 1196103-64-6 2-(3-tert-butyl-isoxazol-5-yl)-5-[1-(4-fluoro-benzenesulfonyl)-1-methyl-ethyl]-[1,3,4]thiadiazole 
• 1196104-30-9 3-tert-butyl-isoxazole-5-carboxylic acid N'-[2-(4-fluoro-benzenesulfonyl)-2-methyl-propionyl]-hydrazide 
• 1196103-48-6 2-(3-tert-butyl-isoxazol-5-yl)-5-[1-(4-fluoro-benzenesulfonyl)-1-methyl-ethyl]-[1,3,4]oxadiazole 

Relevant academic research and scientific papers

INHIBITORS OF BRUTON'S TYROSINE KINASE

This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with exc

Sulfone compounds which modulate the CB2 receptor

Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating p

SUBSTITUTED BENZIMDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS

The present invention is directed to benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia

SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS

The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.

SULFONE COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR

Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating p

Ramoplanin derivatives possessing antibacterial activity

Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

[3 + 2]-Cycloaddition reactions of alkynyl(phenyl)iodonium triflates with ethyl diazoacetate, N-t-butyl-α-phenyl nitrone and t-butylnitrileoxide as 1,3-dipoles

The [3+2]-cycloaddition of various β-substituted ethynyliodonium salts, RC≡CI(+)OTf, with ethyl diazoacetate, N-t-butyl-a-phenyl nitrone and t-butylnitrile oxide results in single regioisomeric pyrroles, dihydroisoxozoles, and isoxazoles respectively in moderate yields.