133691-48-2

Upstream product

• 20256-39-7 N-(5-chlorothiazol-2-yl)acetamide 
• 1193-02-8 4-aminotiophenol 
• 7254-13-9 N-[5-(4-nitro-phenylsulfanyl)-thiazol-2-yl]-acetamide 
• 7439-89-6 iron 
• 2719-23-5 2-acetamidothiazole 

Downstream Products

• 133691-51-7 2-acetylamino-5-(4-aminophenylsulfinyl)thiazole 
• 133691-66-4 2-acetamido-5-(4-methanesulfonylaminophenylthio)thiazole 
• 133691-49-3 2-amino-5-(4-aminophenylthio)thiazole 

Relevant academic research and scientific papers

Discovery of FR115092 : A novel antinephritic agent

A series of dapsone-related 4-aminophenyl and 2-aminothiazolyl derivatives was prepared, and their antinephritic activity and blood toxicity were evaluated. 5-(2-Pyridylsulfonyl)-2-thiazolamine (FR115092,26) was effective against two nephritis models, namely graft-versus-host disease (GVHD) and autoimmune W/BF1 mice, and showed none of the blood toxicity observed with dapsone.

Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same

Compounds of the formula: STR1 wherein A is S, SO, or SO2, R1 is H or acyl, R2 is H, alkyl, hydroxyalkyl, halogen or carboxy, and R3 is pyridyl are claimed. The compounds are useful as therapeutic agents for the treatment of e.g. rheumatism, nephritis and