133706-84-0Relevant academic research and scientific papers
Stereoselective Aldol Reaction with Chiral Acetates
Prasad, Kapa,Chen, Kau-Ming,Repic, Oljan,Hardtmann, Goetz E.
, p. 703 - 706 (1990)
The synthesis of enantiomerically pure 5 is described utilizing chiral acetate 2 and aldehyde 3 employing novel aldol reaction conditions (e.g., the use of excess organic amine compared to n-BuLi for generating the enolate).In addition, some interesting new chiral auxiliaries are also described.
Asymmetric synthesis of 3,5-dihydroxy-6(E)-heptenoate-containing HMG-CoA reductase inhibitors
Tempkin, Orin,Abel, Stephan,Chen, Chung-Pin,Underwood, Russell,Prasad, Kapa,Chen, Kau-Ming,Repic, Oljan,Blacklock, Thomas J.
, p. 10659 - 10670 (2007/10/03)
A 'one-pot' conversion of aldehyde 6 to hydroxyketoester 10 with high enantioselection, culminating in a practical asymmetric synthesis of (3R,5S) isomer of the antihyperlipoproteinemic agent fluvastatin, 1, is described. All four 3,5-dihydroxy-6(E)-heptenoate stereoisomers were prepared in enantiopure form starting from 10, utilizing selective reduction and oxidation methods.
