95061-51-1

Basic information

• Product Name: (S)-(-)-2-HYDROXY-1,2,2-TRIPHENYLETHYL ACETATE
• Synonyms: (S)-(-)-2-Hydroxy-1,2,2-triphenylethyl acetate,99%;(S)-(-)-2-Hydroxy-1,2,2-triphenylethyl acetate(S)-(-)-1,1,2-Triphenyl-1,2-ethanediol 2-acetate;(S)-(-)-1,1,2-Triphenyl-1,2-ethanediol 2-acetate, 98+%;(S)-(-)-HYTRA;(S)-(-)-2-Hydroxy-1,2,3-triphenylethyl acetate;(S)-(-)-2-HYDROXY-1,2,2-TRIPHENYLETHYL A;(1S)-2-Hydroxy-1,2,2-triphenylethyl acetate;(S)-(-)-2-Hydroxy-1,2,2-triphenylethyl acetate for synthesis
• CAS NO: 95061-51-1
• Molecular Formula: C₂₂H₂₀O₃
• Molecular Weight: 332.39
• Product Categories: chiral;Chiral Compound
• Mol File: 95061-51-1.mol

Chemical Properties

• Melting Point: 246-249 °C
• Boiling Point: 429.52°C (rough estimate)
• Flash Point: 197.557 °C
• Appearance: white to light yellow crystal powder
• Density: 1.180
• Vapor Pressure: 2.53E-10mmHg at 25°C
• Refractive Index: 1.6000 (estimate)
• Storage Temp.: Store below +30°C.
• PKA: 12.40±0.29(Predicted)
• CAS DataBase Reference: (S)-(-)-2-HYDROXY-1,2,2-TRIPHENYLETHYL ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-2-HYDROXY-1,2,2-TRIPHENYLETHYL ACETATE(95061-51-1)
• EPA Substance Registry System: (S)-(-)-2-HYDROXY-1,2,2-TRIPHENYLETHYL ACETATE(95061-51-1)

Safety Data

• Safety Statements: 24/25
• WGK Germany: WGK 3 highly water endangering
• Hazardous Substances Data: 95061-51-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(S)-(-)-2-HYDROXY-1,2,2-TRIPHENYLETHYL ACETATE is used as a reactant in the synthesis of Lankacidin derivatives, which are 17-membered macrocyclic antibiotics. These antibiotics exhibit potent antimicrobial activity against a wide range of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). The unique macrocyclic structure of Lankacidin derivatives allows them to target specific bacterial proteins, leading to their potent and selective antimicrobial action.

InChI:InChI=1/C22H20O3/c1-17(23)25-21(18-11-5-2-6-12-18)22(24,19-13-7-3-8-14-19)20-15-9-4-10-16-20/h2-16,21,24H,1H3/t21-/m0/s1

Upstream product

• 108-86-1 bromobenzene 
• 13704-09-1 (S)-(-)-ethyl mandelate 
• 75-36-5 acetyl chloride 
• 21210-43-5 (S)-Methyl mandelate 
• 17199-29-0 (S)-Mandelic acid 
• 108998-83-0 (S)-1,1,2-triphenyl-1,2-ethanediol 

Downstream Products

• 118219-45-7 (3S,4S)-4-Benzyloxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid (S)-2-hydroxy-1,2,2-triphenyl-ethyl ester 
• 115407-88-0 (1'S,3R,5S)-3,5,6-trihydroxy-5,6-O-isopropylidenehexanoic acid 2'-hydroxy-1',2',2'-triphenylethyl ester 
• 115407-87-9 (1'S,3S,5S)-3,5,6-trihydroxy-5,6-O-isopropylidenehexanoic acid 2'-hydroxy-1',2',2'-triphenylethyl ester 
• 129600-88-0 (Z)-(S)-4-Fluoro-3-hydroxy-6-phenyl-hex-4-enoic acid (S)-2-hydroxy-1,2,2-triphenyl-ethyl ester 
• 129600-88-0 (Z)-(R)-4-Fluoro-3-hydroxy-6-phenyl-hex-4-enoic acid (S)-2-hydroxy-1,2,2-triphenyl-ethyl ester 
• 108998-83-0 (S)-1,1,2-triphenyl-1,2-ethanediol 
• 194934-95-7 ((S)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-6-heptenoic acid 1,1-dimethylethyl ester 
• 210690-73-6 (1S)-2-Hydroxy-1,2,2-triphenylethyl (3S,5E)-5-ethyl-3-hydroxy-4,4-dimethyl-5-heptenoate 
• 1024024-27-8 (3S)-5-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-4-pentenoic acid (1S)-2-hydroxy-1,2,2-triphenylethyl ester 
• 118219-44-6 (3S,4S)-4-tert-Butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid (S)-2-hydroxy-1,2,2-triphenyl-ethyl ester 
• 128013-71-8 (3S,4S)-Boc-statine 1,1,2-triphenylethyl ester 
• 128053-07-6 (3R,4S)-Boc-statine 1,1,2-triphenylethyl ester 
• 128013-71-8 (4S)-Boc-statine 1,1,2-triphenylethyl ester 
• 58521-49-6 (3S,4S)-4-(tert-butoxycarbonylamino)-3-hydroxy-6-methylheptanoic acid 

Relevant articles and documents

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Stereoselective Aldol Reactions with (R)- and (S)-2-Hydroxy-1,2,2-triphenylethyl Acetate and Related Glycol Monoacetates

The enolate 7a, formed by double deprotonation of the ester 5a, is added to aldehydes.The influences of the enolate gegenion, of the solvent, and of the reaction temperature on the ratio of the isomeric products 9:10 are studied.The highest degrees of dia