Stereoselective Aldol Reaction with Chiral Acetates

DOI: 10.1016/S0957-4166(00)82378-2

Source and publish data:

Tetrahedron Asymmetry p. 703 - 706 (1990)

Update date:2022-08-06

Topics:

Authors:

Prasad, Kapa

Chen, Kau-Ming

Repic, Oljan

Hardtmann, Goetz E.

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Article abstract of DOI:10.1016/S0957-4166(00)82378-2

The synthesis of enantiomerically pure 5 is described utilizing chiral acetate 2 and aldehyde 3 employing novel aldol reaction conditions (e.g., the use of excess organic amine compared to n-BuLi for generating the enolate).In addition, some interesting new chiral auxiliaries are also described.

Full text of DOI:10.1016/S0957-4166(00)82378-2

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Product name:(E)-(S)-5-[3-(4-Fluoro-phenyl)-5-isopropyl-2-phenyl-3H-imidazol-4-yl]-3-hydroxy-pent-4-enoic acid (S)-2-hydroxy-1,2,2-triphenyl-ethyl ester

Cas No:133706-84-0

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