133712-40-0Relevant academic research and scientific papers
Aryloxyphenylpropylamines their preparation and use
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, (2008/06/13)
Novel aryloxyphenylpropylamines having the formula STR1 wherein X is H, cyano, halogen, halogenoalkyl, C1-6 -alkoxy, C1-6 -alkyl, C1-5 -alkanoyl, C3-5 -alkylene, aryloxy or aralkoxy, and R is 3,4-methylenedioxy, aryl or heteroaryl which are optionally substituted with one or more cyano, halogeno, C1-6 -alkyl, C1-6 -alkoxy, C1-6 -alkenyl, trifluoromethyl, C3-5 -alkylene, aryloxy or aralkoxy; and R1 and R2 independently is C1-10 -alkyl, C3-7 -cycloalkyl, C2-10 -alkenyl, C3-6 -cycloalkyl-C1-5 -alkyl, optionally substituted with C1-5 -alkoxy or cyano; R1 and R2 may together form a carbocyclic ring and a salt thereof with a pharmaceutically acceptable acid, provided however that R1 is not C3-7 -cycloalkyl, C1-10 -alkyl, or alkenyl which may be straight, branched or cyclic, unsubstituted or substituted with C1-4 -alkoxy, aryloxy or cycloalkyl or cycloalkylalkyl, when X is H and R2 is a methyl group. The novel compounds are useful in the treatment of anoxia, migraine, ischemia, epilepsy, traumatic injury and neurodegenerative diseases.
