133715-45-4

Upstream product

• 51594-55-9 (R)-(-)-epichlorohydrin 
• 30818-28-1 5-chloro-2-cyanophenol 
• 115314-14-2 (R)-glycidyl nosylate 
• 203259-53-4 4-Chloro-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-benzonitrile 
• 203259-54-5 4-Chloro-2-((R)-2,3-dihydroxy-propoxy)-benzonitrile 
• 203259-52-3 ethyl 6-chloro-1,2-benzisoxazole-3-carboxylate 
• 203259-55-6 Toluene-4-sulfonic acid (S)-3-(5-chloro-2-cyano-phenoxy)-2-hydroxy-propyl ester 

Relevant academic research and scientific papers

Studies on agents with vasodilator and β-blocking activities. V. Synthesis and pharmacological activity of the optical isomers of TZC-5665

Synthesis of the four optical isomers of TZC-5665 (1), a candidate for the treatment of congestive heart failure, was achieved by the reaction of chiral diaminopyridazinone (2) with chiral glycidyl ether (3). The hypotensive and β-blocking activities of 1 and its optical isomers were examined when given intravenously into anesthetized rats. Furthermore these compounds were evaluated for inhibitory activity on cAMP phosphodiesterase III. Among the four optical isomers, R(A),S(B)-one (1c) possessed the essential activities of TZC-5665 (1).