203259-53-4

Basic information

• Product Name: 4-Chloro-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-benzonitrile
• Synonyms: 4-Chloro-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-benzonitrile
• CAS NO: 203259-53-4
• Molecular Weight: 267.712
• Mol File: 203259-53-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Chloro-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-benzonitrile(203259-53-4)
• EPA Substance Registry System: 4-Chloro-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-benzonitrile(203259-53-4)

Safety Data

• Hazardous Substances Data: 203259-53-4(Hazardous Substances Data)

Upstream product

• 203259-52-3 ethyl 6-chloro-1,2-benzisoxazole-3-carboxylate 
• 30818-28-1 5-chloro-2-cyanophenol 
• 23788-74-1 (R)-2,2-dimethyl-1,3-dioxolane-4-ylmethyl p-toluenesulfonate 

Downstream Products

• 203259-31-8 (R)-(-)-1-(5-chloro-2-cyanophenoxy)-2,3-epoxypropane 
• 133715-45-4 (S)-(+)-1-(5-chloro-2-cyanophenoxy)-2,3-epoxypropane 
• 203259-55-6 Toluene-4-sulfonic acid (S)-3-(5-chloro-2-cyano-phenoxy)-2-hydroxy-propyl ester 
• 203259-54-5 4-Chloro-2-((R)-2,3-dihydroxy-propoxy)-benzonitrile 

Relevant articles and documents

Studies on agents with vasodilator and β-blocking activities. V. Synthesis and pharmacological activity of the optical isomers of TZC-5665

Synthesis of the four optical isomers of TZC-5665 (1), a candidate for the treatment of congestive heart failure, was achieved by the reaction of chiral diaminopyridazinone (2) with chiral glycidyl ether (3). The hypotensive and β-blocking activities of 1 and its optical isomers were examined when given intravenously into anesthetized rats. Furthermore these compounds were evaluated for inhibitory activity on cAMP phosphodiesterase III. Among the four optical isomers, R(A),S(B)-one (1c) possessed the essential activities of TZC-5665 (1).