1337482-17-3 Usage
Uses
Different sources of media describe the Uses of 1337482-17-3 differently. You can refer to the following data:
1. Sofosbuvir Impurity
2. Sofosbuvir 3'',5''-Bis-(S)-phosphate is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
Check Digit Verification of cas no
The CAS Registry Mumber 1337482-17-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,7,4,8 and 2 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1337482-17:
(9*1)+(8*3)+(7*3)+(6*7)+(5*4)+(4*8)+(3*2)+(2*1)+(1*7)=163
163 % 10 = 3
So 1337482-17-3 is a valid CAS Registry Number.
1337482-17-3Relevant articles and documents
Mechanism-Based Solution to the ProTide Synthesis Problem: Selective Access to Sofosbuvir, Acelarin, and INX-08189
Simmons, Bryon,Liu, Zhuqing,Klapars, Artis,Bellomo, Ana,Silverman, Steven M.
supporting information, p. 2218 - 2221 (2017/05/12)
A general and efficient method for the synthesis of pronucleotide (ProTide) 5'-phosphoramidate monoesters is reported. This method consists of a highly stereoselective 5'-phosphorylation mediated by dimethylaluminum chloride to afford the desired target ProTides in excellent yields without employing 3'-protection strategies. The application of this methodology to the synthesis of a number of pharmaceutically relevant compounds currently marketed or under investigation in clinical research is demonstrated.