1337482-17-3 Usage
Uses
Used in Pharmaceutical Industry:
L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 1-Methylethyl ester, (P→3'),(P'→5')-diester with (2'R)-2'-deoxy-2'-fluoro-2'-Methyluridine is used as an intermediate or building block for the synthesis of various pharmaceutical compounds. Its unique structure and functional groups make it a valuable component in the development of new drugs, particularly those targeting specific biological pathways or receptors.
Used in Antiviral Applications:
In the context of antiviral research, L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 1-Methylethyl ester, (P→3'),(P'→5')-diester with (2'R)-2'-deoxy-2'-fluoro-2'-Methyluridine is used as an impurity of Sofosbuvir 3'',5''-Bis-(S)-phosphate, which is a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate. This active agent is a nucleotide inhibitor of the hepatitis C virus, specifically targeting the HCV NS5B polymerase. The compound's role in the development and production of antiviral drugs highlights its importance in the fight against viral infections, particularly hepatitis C.
Used in Research and Development:
Due to its complex structure and potential applications, L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 1-Methylethyl ester, (P→3'),(P'→5')-diester with (2'R)-2'-deoxy-2'-fluoro-2'-Methyluridine is also used in research and development settings. Scientists and researchers may utilize L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 1-Methylethyl ester, (P→3'),(P'→5')-diester with (2'R)-2'-deoxy-2'-fluoro-2'-Methyluridine to study its properties, interactions with biological systems, and potential applications in various fields, including drug discovery, chemical synthesis, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 1337482-17-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,7,4,8 and 2 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1337482-17:
(9*1)+(8*3)+(7*3)+(6*7)+(5*4)+(4*8)+(3*2)+(2*1)+(1*7)=163
163 % 10 = 3
So 1337482-17-3 is a valid CAS Registry Number.
1337482-17-3Relevant academic research and scientific papers
Mechanism-Based Solution to the ProTide Synthesis Problem: Selective Access to Sofosbuvir, Acelarin, and INX-08189
Simmons, Bryon,Liu, Zhuqing,Klapars, Artis,Bellomo, Ana,Silverman, Steven M.
supporting information, p. 2218 - 2221 (2017/05/12)
A general and efficient method for the synthesis of pronucleotide (ProTide) 5'-phosphoramidate monoesters is reported. This method consists of a highly stereoselective 5'-phosphorylation mediated by dimethylaluminum chloride to afford the desired target ProTides in excellent yields without employing 3'-protection strategies. The application of this methodology to the synthesis of a number of pharmaceutically relevant compounds currently marketed or under investigation in clinical research is demonstrated.
SELECTIVE PROCESS FOR SYNTHESIS OF NUCLEOSIDE PHOSPHORAMIDATES
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Page/Page column 133, (2016/12/22)
A process for preparing a nucleoside phosphoramidate, in particular to a process for preparing sofosbuvir, wherein a phosphoramidate derivative is used as starting material.
