133775-65-2

Upstream product

• 88319-56-6 N-tert-butoxycarbonyl-p-nitrophenylalanine N-hydroxysuccinimidyl ester 
• 1121-22-8 trans-1,2-Diaminocyclohexane 
• 133725-76-5 (1R,2R)-N-[2-Amino-3-(4-nitro-phenyl)-propyl]-cyclohexane-1,2-diamine 
• 133725-75-4 N-tert-butoxycarbonyl-N'-(trans-2-aminocyclohexyl)-p-nitrophenylalaninamide 
• 86937-80-6 2-tert-butoxycarbonylamino-3-(4-nitro-phenyl)-propionic acid 
• 142350-84-3 2-Amino-N-((1S,2S)-2-amino-cyclohexyl)-3-(4-nitro-phenyl)-propionamide; hydrochloride 
• 290836-21-4 {[(1S,2S)-2-(Bis-tert-butoxycarbonylmethyl-amino)-cyclohexyl]-[(S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitro-phenyl)-propyl]-amino}-acetic acid tert-butyl ester 

Downstream Products

• 133725-78-7 N-[2-amino-3-(p-aminophenyl)propyl]-trans-cyclohexane-1,2-diamine-N,N',N',N,N-pentaacetic acid 
• 133725-78-7 N-<2-amino-3-(p-aminophenyl)propyl>-trans-cyclohexane-1,2-diamine-N,N',N'N'',N''-penta-acetic acid 
• 133725-79-8 N-<2-amino-3-(p-isothiocyanatophenyl)propyl>-trans-cyclohexane-1,2-diamine-N,N',N'N'',N''-penta-acetic acid 
• 133725-78-7 N-<2-amino-3-(p-aminophenyl)propyl>-trans-cyclohexane-1,2-diamine-N,N',N'N'',N''-penta-acetic acid 
• 133725-79-8 N-<2-amino-3-(p-isothiocyanatophenyl)propyl>-trans-cyclohexane-1,2-diamine-N,N',N'N'',N''-penta-acetic acid 
• 133775-66-3 {[(S)-3-(4-Amino-phenyl)-2-(bis-carboxymethyl-amino)-propyl]-[(1S,2S)-2-(bis-carboxymethyl-amino)-cyclohexyl]-amino}-acetic acid 
• 157380-45-5 {[(1S,2S)-2-(Bis-carboxymethyl-amino)-cyclohexyl]-[(S)-2-(bis-carboxymethyl-amino)-3-(4-isothiocyanato-phenyl)-propyl]-amino}-acetic acid 
• 133725-79-8 {[(1S,2S)-2-(Bis-carboxymethyl-amino)-cyclohexyl]-[2-(bis-carboxymethyl-amino)-3-(4-isothiocyanato-phenyl)-propyl]-amino}-acetic acid 

Relevant academic research and scientific papers

Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-(p- nitrobenzyl)-trans-CyDTPA

Distinct differences in in vivo stability of the two diastereomeric C- Functionalized CyDTPA chelating agents, (CHX-A DTPA and CHX-B DTPA, both racemates), as recently reported prompted further investigation as to why differences in configuration produced striking effects on the in vivo stability of their yttrium complexes. To this end, the four individual component stereoisomers of CHX-A and CHX-B were synthesized and ability to bind yttrium was investigated both in vitro and in vivo.

Synthesis of C-Functionalized trans-Cyclohexyldiethylenetriaminepenta-acetic Acids for Labelling of Monoclonal Antibodies with the Bismuth-212 α-Particle Emitter

Several C-functionalized cyclohexyldiethylenetriaminepenta-acetic acid derivatives have been prepared from (+/-)-4-nitrophenylalanine and (+/-)-trans-cyclohexane-1,2-diamine to produce two sets of diastereoisomeric enantiomers.A modification of this synth

An Effective Chelating Agent for Labelling of Monoclonal Antibody with 212Bi for &α-Particle Mediated Radioimmunotherapy

The ligand N--(+/-)trans-1,2-diaminocyclohexane-N,N',N''-pentaacetic acid has been synthesized and linked to lgG and to monoclonal antibody B72.3 and labelled with 206Bi and 212Bi to demonstrate the in vivo stabil