1337883-13-2

Upstream product

• 174535-84-3 5-amino-6-mercapto-1-phenyl-1,5-dihydropyrazolo[3,4-d]pyrimidin-4-one 
• 16078-71-0 ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate 
• 1337883-12-1 2-chloromethyl-8-phenylpyrazolo[3,4-d][1,3,4]thiadiazolo[3,2-a]pyrimidin-4(1H)-one 
• 74-89-5 methylamine 

Relevant academic research and scientific papers

A novel and eco-friendly procedure for the synthesis of some pyrazolo-thiadiazolo-pyrimidinones and its in vitro anti-bacterial activity

A novel series of 2-substituted-aminomethyl-8-phenyl-pyrazolo[3,4-d][1,3,4] thiadiazolo[3,2-a]pyrimidin-4 (1H)-ones have been synthesized by treating 2-chloromethyl-8-phenyl-pyrazolo[3,4-d][1,3,4]thiadiazolo[3,2-a] pyrimidin-4(1H)-one with various nucleophiles. The chloromethyl derivative was prepared by treating 2-amino-3-mercapto pyrazolo[3,4-d]pyrimidine with one carbon donor, chloroacetic acid. The intermediate 2-amino-3-mercapto pyrazolo[3,4-d]pyrimidine was prepared by a novel, eco-friendly route starting from 2-amino-3-carbethoxy-1-phenyl-pyrazole. The target compounds exhibited broad-spectrum antibacterial activity (Kirby Bauer's Method). Springer Science+Business Media, LLC 2011.