1337966-39-8Relevant articles and documents
Acyl hydrazides as peptoid sub-monomers
Kanta Sarma, Bani,Yousufuddin, Muhammed,Kodadek, Thomas
, p. 10590 - 10592 (2011)
The use of acyl hydrazides as peptoid sub-monomers is investigated. We demonstrate here that azapeptoids derived entirely from acyl hydrazides can be made conveniently and efficiently using standard peptoid sub-monomer chemistry. Structural studies reveal that the main chain amide bond in these molecules predominantly adopts a trans conformation. A high-quality one bead one compound library of tetramers was made by split and pool synthesis and we found that the identity of the molecule on a single bead could be determined by tandem MALDI mass spectrometry.