1337994-16-7

Basic information

• Product Name: C₅₁H₇₄N₅O₁₁PS
• CAS NO: 1337994-16-7
• Molecular Weight: 996.215
• Mol File: 1337994-16-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₅₁H₇₄N₅O₁₁PS(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₁H₇₄N₅O₁₁PS(1337994-16-7)
• EPA Substance Registry System: C₅₁H₇₄N₅O₁₁PS(1337994-16-7)

Safety Data

• Hazardous Substances Data: 1337994-16-7(Hazardous Substances Data)

Upstream product

• 1337994-15-6 C₄₂H₅₇N₃O₁₀S 
• 102691-36-1 N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite 
• 112-60-7 Tetraethylene glycol 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 86770-74-3 11-amino-3,6,9-trioxaundecanol 
• 86770-67-4 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol 
• 65883-12-7 2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethyl methanesulfonate 
• 58-85-5 biotin 

Relevant articles and documents

Synthesis of biotin-containing phosphoramidite linker with polyether spacer arm

A phosphoramidite linker unit, based on glycerol backbone and containing a biotin residue attached through a tetraethylene glycol spacer arm, was synthesized. DMTr-Glycidol and tetraethylene glycol were used as starting materials. After conversion of one of hydroxy groups in tetraethylene glycol into an amino group, the epoxy cycle in DMTr-glycidol was opened by this amino alcohol, resulting in the corresponding ether and some quantity of secondary amine. After attaching of biotin residue to the ether followed by phosphitylation, the desirable linker was obtained. The structure of the linker was confirmed by 1H-1H COSY, 1H-13C HSQC, 1H-13C HMBC, 1H-15N HSQC, and 1H-15N HMBC spectra. The resulted phosphoramidite linker unit is suitable for use in common DNA synthesizers. This approach can be used for preparation of various modifiers containing reporter groups attached to the primary amino function using conventional procedures. Copyright Taylor and Francis Group, LLC.