65883-12-7

Basic information

• Product Name: 1-METHANESULFONYL-11-HYDROXY-3,6,9-TRIOXAUNDECANE
• Synonyms: 1-METHANESULFONYL-11-HYDROXY-3,6,9-TRIOXAUNDECANE;3,6,9,12-Tetraoxa-2-thiatetradecan-14-ol 2,2-Dioxide;PEG5-Ms
• CAS NO: 65883-12-7
• Molecular Formula: C₉H₂₀O₇S
• Molecular Weight: 256.32
• Product Categories: Nitric Oxide Reagents;Cross Linking Reagents
• Mol File: 65883-12-7.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 430.6±35.0 °C(Predicted)
• Appearance: /
• Density: 1.231±0.06 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform, Methanol
• PKA: 14.36±0.10(Predicted)
• CAS DataBase Reference: 1-METHANESULFONYL-11-HYDROXY-3,6,9-TRIOXAUNDECANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHANESULFONYL-11-HYDROXY-3,6,9-TRIOXAUNDECANE(65883-12-7)
• EPA Substance Registry System: 1-METHANESULFONYL-11-HYDROXY-3,6,9-TRIOXAUNDECANE(65883-12-7)

Safety Data

• Hazardous Substances Data: 65883-12-7(Hazardous Substances Data)

Usage

Description

PEG5-Ms is a PEG linker with a mesyl group and a hydroxyl group. The mesyl group is good leaving groups but can also be used as protecting groups for primary alcohols. They can be deprotected in the presence of sodium amalgam. The hydroxyl group can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.

Chemical Properties

Brown Oily Residue

Uses

1-Methanesulfonyl-11-hydroxy-3,6,9-trioxaundecane (cas# 65883-12-7) is a compound useful in organic synthesis.

Upstream product

• 112-60-7 Tetraethylene glycol 
• 124-63-0 methanesulfonyl chloride 
• 134179-38-7 2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethylamine 
• 101187-39-7 1,11-diazido-3,6,9-trioxaundecane 
• 55400-73-2 ((oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) dimethanesulfonate 
• 914311-67-4 N-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)-5-(dimethylamino)naphthalene-1-sulfonamide 
• 1321923-30-1 N-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)-5-(dimethylamino)naphthalene-1-sulfonamide 

Downstream Products

• 86770-67-4 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol 
• 101187-40-0 1-Boc-amine-11-amino-3,6,9-trioxaundecane 
• 642091-68-7 tert-butyl N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]carbamate 
• 1416735-27-7 N¹-((1-(3,6,9,12-tetraoxapentadec-14-ynyl)-1H-1,2,3-triazol-4-yl)bis(4-fluorophenyl)methoxy)-N⁸-phenyloctanediamide 
• 1416735-24-4 (1-(3,6,9,12-tetraoxapentadec-14-ynyl)-1H-1,2,3-triazol-4-yl)bis(4-fluorophenyl)methanol 
• 1416735-20-0 2-(2-(2-(2-(4-(hydroxy)bis(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethanol 
• 1442461-47-3 N-((1-(3,6,9,12-tetraoxapentadec-14-ynyl)-1H-1,2,3-triazol-4-yl)bis(4-fluorophenyl)methoxy)phenyl 
• 1416735-28-8 C₂₆H₂₈ClF₂N₃O₄ 
• 134179-38-7 2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethylamine 
• 936917-36-1 1-azido-2-(2-(2-(2-iodoethyoxy)ethoxy)ethoxy)ethane 

Relevant articles and documents

Polymer-supported cationic templates for molecular recognition of anionic hosts in water

Translocating solution-phase molecular recognition of oppositely charged hosts and guests to the solid phase represents a major challenge; we report a successful immobilisation strategy which allows selective host-guest interactions in water unencumbered by unwanted ion exchange-type interactions. The Royal Society of Chemistry.

A MedChem toolbox for cereblon-directed PROTACs

A modular chemistry toolbox was developed for cereblon-directed PROTACs. A variety of linkers was attached to a CRBN ligand via the 4-amino position of pomalidomide. We used linkers of different constitution to modulate physicochemical properties. We equipped one terminus of the linker with a set of functional groups, e.g. protected amines, protected carboxylic acids, alkynes, chloroalkanes, and protected alcohols, all of which are considered to be attractive for PROTAC design. We also highlight different opportunities for the expansion of the medicinal chemists' PROTAC toolbox towards heterobifunctional molecules, e.g. with biotin, fluorescent, hydrophobic and peptide tags.

Ionic liquid and preparation method and application of ionic liquid

The invention relates to the field of electrolyte materials and discloses ionic liquid and a preparation method and application of the ionic liquid. The method comprises the following steps: 1) carrying out first reaction on methanesulfonyl chloride and at least one substance with a structure shown as a formula (2); 2) carrying out second reaction on an organic product obtained by the first reaction of the step 1) and a substance with a structure shown as a formula (3). According to the ionic liquid disclosed by the invention, defects that a traditional ionic liquid preparation process is complicated and the safety is low are overcome; the method provided by the invention is simple and feasible; preparation parameters have high controllability; the preparation method has the advantages of low cost and high efficiency; polymerized ionic liquid prepared from the ionic liquid has relatively high ionic conductivity and a wide electrochemical window, and has a very good industrial application prospect. (The formula (2) and the formula (3) are shown as the description.).