1338208-79-9

Basic information

• Product Name: methyl 5-((5-benzyl-1,3,4-thiadiazol-2-yl)amino)-5-oxo-pentanoate
• Synonyms: methyl 5-((5-benzyl-1,3,4-thiadiazol-2-yl)amino)-5-oxo-pentanoate
• CAS NO: 1338208-79-9
• Molecular Weight: 319.384
• Mol File: 1338208-79-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 5-((5-benzyl-1,3,4-thiadiazol-2-yl)amino)-5-oxo-pentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 5-((5-benzyl-1,3,4-thiadiazol-2-yl)amino)-5-oxo-pentanoate(1338208-79-9)
• EPA Substance Registry System: methyl 5-((5-benzyl-1,3,4-thiadiazol-2-yl)amino)-5-oxo-pentanoate(1338208-79-9)

Safety Data

• Hazardous Substances Data: 1338208-79-9(Hazardous Substances Data)

Upstream product

• 1119-40-0 Dimethyl glutarate 
• 16502-08-2 5-benzyl-[1,3,4]thiadiazol-2-ylamine 
• 1501-26-4 methyl 4-(chlorocarbonyl)butyrate 

Downstream Products

• 1338208-97-1 N₁-(5-benzyl-1,3,4-thiadiazol-2-yl)-N₅-hydroxyglutaramide 

Relevant articles and documents

Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors

Histone deacetylase (HDAC) inhibitors have emerged as a new class of anticancer agents, targeting the biological processes including cell cycle, apoptosis and differentiation. In the present study, a series of 1,3,4-thiadiazole based hydroxamic acids were developed as potent HDAC inhibitors. Some of them showed good inhibitory activity in HDAC enzyme assay and potent growth inhibition in some tumor cell lines. Among them, compound 6i (IC50 = 0.089 μM), exhibited better inhibitory effect compared with SAHA (IC50 = 0.15 μM).