1338248-76-2

Basic information

• Product Name: 3-(4-methoxyphenyl)-imidazo[1,2-a]pyridine
• Synonyms: 3-(4-methoxyphenyl)-imidazo[1,2-a]pyridine
• CAS NO: 1338248-76-2
• Molecular Weight: 224.262
• Mol File: 1338248-76-2.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: 3-(4-methoxyphenyl)-imidazo[1,2-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methoxyphenyl)-imidazo[1,2-a]pyridine(1338248-76-2)
• EPA Substance Registry System: 3-(4-methoxyphenyl)-imidazo[1,2-a]pyridine(1338248-76-2)

Safety Data

• Hazardous Substances Data: 1338248-76-2(Hazardous Substances Data)

Upstream product

• 504-29-0 2-aminopyridine 
• 274-76-0 imidazo[1,2-a]pyridine 
• 100-66-3 methoxybenzene 
• 32687-32-4 3-(4-methoxyphenyl)-2H-azirine 
• 34910-42-4 1-(1-azidovinyl)-4-methoxybenzene 
• 637-69-4 4-Methoxystyrene 
• 274-87-3 tetrazolo[1,5-a]pyridine 
• 768-60-5 4-methoxyphenylacetylen 
• 5703-26-4 4-Methoxyphenylacetaldehyde 
• 623-12-1 4-chloromethoxybenzene 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 6200-60-8 imidazo[1,2-a]pyridine-3-carboxylic acid 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 60512-57-4 1-(2,2-dibromovinyl)-4-methoxybenzene 

Relevant articles and documents

Synthesis of Imidazo[1,2- a]pyridines: Triflic Anhydride-Mediated Annulation of 2 H-Azirines with 2-Chloropyridines

The discovery and optimization of a reaction between 2-chloropyridines and 2H-azirines producing imidazo[1,2-a]pyridines is described. The treatment of 2H-azirines with triflic anhydride (Tf2O) forms an electrophilic 1-trifloyl-aziridin-2-yl triflate spec

Iron(II)-Based Metalloradical Activation: Switch from Traditional Click Chemistry to Denitrogenative Annulation

A unique concept for the intermolecular denitrogenative annulation of 1,2,3,4-tetrazoles and alkynes was discovered by using a catalytic amount of Fe(TPP)Cl and Zn dust. The reaction precludes the traditional, more favored click reaction between an organic azide and alkynes, and instead proceeds by an unprecedented metalloradical activation. The method is anticipated to advance access to the construction of important basic nitrogen heterocycles, which will in turn enable discoveries of new drug candidates.

Exploring Green Solvents Associated to Pd/C as Heterogeneous Catalyst for Direct Arylation of Heteroaromatics with Aryl Bromides

Metal residues are certainly one of the major sources of contamination of products in metal-catalyzed direct arylation reactions. We found that the use of only 1 mol% of the heterogeneous catalyst Pd/C promotes very efficiently the direct arylations of most heteroaromatics. In the presence of this catalyst and potassium acetate as the base, the direct arylation of thiophenes, furans, pyrroles, thiazoles, imidazoles or isoxazoles, using aryl bromides as coupling partners, proceeds highly regioselectively and in moderate to very high yields. With several heteroarenes both electron-deficient and electron-rich aryl bromides were tolerated; moreover, with the most reactive heteroarenes, the Pd/C catalyst tolerated green solvents such as diethyl carbonate, 3-methylbutan-1-ol and pentan-1-ol, affording a synthetic scheme with low environmental impact. (Figure presented.).