1338249-35-6Relevant articles and documents
Discovery of novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 inhibitors
Zeng, Hongbo,Belanger, David B.,Curran, Patrick J.,Shipps Jr., Gerald W.,Miao, Hua,Bracken, Jack B.,Arshad Siddiqui,Malkowski, Michael,Wang, Yan
, p. 5870 - 5875 (2011/10/09)
A series of substituted imidazo[1,2-a]pyrazin-8-amines were discovered as novel breast tumor kinase (Brk)/protein tyrosine kinase 6 (PTK6) inhibitors. Tool compounds with low-nanomolar Brk inhibition activity, high selectivity towards other kinases and desirable DMPK properties were achieved to enable the exploration of Brk as an oncology target.