133825-87-3Relevant academic research and scientific papers
Synthesis and Evaluation of 11C- And 18F-Labeled SOAT1 Inhibitors as Macrophage Foam Cell Imaging Agents
Arteaga, Janna,Brooks, Allen F.,Hill, James R.,Scott, Peter J. H.,Shao, Xia,Sherman, Phillip S.,Stauff, Jenelle,Viglianti, Benjamin L.,Wong, Ka Kit,Wright, Jay S.
supporting information, p. 1299 - 1304 (2020/07/03)
PD-132301, an inhibitor of sterol O-acyltransferase 1 (SOAT1; also known as acyl-coenzyme A:cholesterol acyltransferase-1, ACAT1), is under clinical investigation for numerous adrenal disorders. Radiolabeled SOAT1 inhibitors could support drug discovery a
ENHANCED BIOAVAILABILITY OF N-(2,6-BIS(1-METHYLETHYL) PHENYL)-N'-((1-(4-(DIMETHYLAMINO)-PHENYL)CYCLOPENTYL) METHYL)UREA HYDROCHLORIDE
-
Page/Page column 16-17, (2017/02/09)
Methods for enhancing the bioavailability of N-(2,6-bis(1-methylethyl)phenyl)-N'-((1-(4-(dimethylamino)phenyl)cyclopentyl)-methyl)urea hydrochloride (ATR-101)through administration with food, and compositions and kits related thereto.
SOLID DRUG FORM OF N-(2,6-BIS(1-METHYLETHYL)PHENYL)-N'-((1-(4-(DIMETHYLAMINO)PHENYL)CYCLOPENTYL)METHYL)UREA HYDROCHLORIDE AND COMPOSITIONS, METHODS AND KITS RELATED THERETO
-
Page/Page column 19, (2016/04/26)
A novel solid drug form of N-(2,6-bis(1-methylethyl)phenyl)-N′-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea hydrochloride (also referred to “ATR-101”) suitable for oral dosing, and to compositions, methods and kits relating thereto. ATR-101 has particular utility in the treatment of, for example, aberrant adrenocortical cellular activity, including adrenocortical carcinoma (ACC), congenital adrenal hyperplasia (CAH) and Cushing's syndrome.
Inhibitors of Acyl-CoA: Cholesterol Acyltransferase (ACAT). 7. Development of a Series of Substituted N-Phenyl-N'-ureas with Enhanced Hypocholesterolemic Activity
Trivedi, Bharat K.,Purchase, Terri Stoeber,Holmes, Ann,Augelli-Szafran, Corinne E.,Essenburg, Arnold D.,et al.
, p. 1652 - 1659 (2007/10/02)
We recently described our initial structure-activity relationship (SAR) studies on a series of N-phenyl-N'-aralkyl- and N-phenyl-N'-(1-phenylcycloalkyl)ureas as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT).From this series of analogs, compou
Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds
-
, (2008/06/13)
Certain substituted urea, thiourea, carbamate, and thiocarbamate compounds are potent inhibitors of the enzyme acyl-CoA: cholesterol acyltransferase and are thus useful agents for inhibiting the intestinal absorption of cholesterol, and for lowering blood
