1338382-65-2Relevant academic research and scientific papers
Diastereoselective access to tri-and pentacyclic spiro-γ-lactam- oxindole cores through a tandem aza-michael initiated ring closure sequence
Allous, Iyad,Comesse, Sebastien,Sanselme, Morgane,Daich, Adam
, p. 5303 - 5310 (2011)
Herein, we present a new development of the previously described aza-Michael-initiated ring closure (MIRC) process to access spirooxindole cores. The key spiro-cyclization step between various α-bromoacetamides and methyleneindolinones was efficient and tolerant of a wide range of functional groups. Yields and diastereoselectivities for the spirocyclization were usually high and furnished original spiro[oxindole-3,3′-γ-lactam] derivatives. The utility of these novel building blocks for the preparation of more sophisticated derivatives was demonstrated by the preparation of four pentacyclic spirooxindoles.
