26960-68-9Relevant articles and documents
Synthesis, structural properties and potent bioactivities supported by molecular docking and DFT studies of new hydrazones derived from 5-chloroisatin and 2-thiophenecarboxaldehyde
Ahmed, Kainat,Ahmed, Maqsood,Arshad, Muhammad,Bashir, Maryam,Kanwal, Maleeha,Khan, Hidayat Ullah,Khan, Shahnaz,Kosar, Naveen,Mahmood, Tariq,Rauf, Abdul,Waseem, Amir
, (2021)
New hydrazones were synthesized by employing a convergent synthetic methodology involving condensation of N-alkyl 5-chloroisatins with hydrazone derived from 2-thiophenecarboxaldehyde. The synthesized compounds were fully characterized using UV/Vis., Infrared, 1H and 13C NMR spectroscopies as well as single crystal X-rays diffraction analysis. Bader's theory of ‘atoms in molecules’ confirmed the existence of all nonbonding interactions. Connectivity between isomers of synthesized compounds was characterized by the distribution of critical points, isatin surfaces, and bond paths. The presence of electrostatic potential on oxygen and hydrogen atoms was evaluated by means of MEP calculations, which showed that the oxygen atom acts as nucleophilic center for electrophilic hydrogen atom. Compound 6 exhibited potent anti-oxidant potential (DPPH, ABTS, NBT) with IC50 values of 46 ± 0.72 μM/mL. These compounds were also screened for in vitro cholinesterases inhibition, where compound 6 presented effective inhibition against AChE and BChE in comparison to the standard drugs; allanzanthane and galanthamine in a dose reliant mode. The IC50 values of both compounds (6 and 7) against AChE were determined to be 20.21 ± 0.06 & 16.22 ± 0.18 μM and against BChE, as 28.01 ± 0.01 & 20.11 ± 0.12 μM, respectively. Molecular docking studies supported these results and helped to establish structure activity relationship. The results reported in this manuscript are anticipated to be beneficial for understanding the solid-state architecture of the X-ray structures of new hydrazone conjugates of 5-chloroisatin & 2-thiophenecarboxaldehyde. On the other hand their intriguing biological potentials can create quest among scientific community to further analyze such molecules for drug discovery purposes.
Novel 2-indolinone thiazole hybrids as sunitinib analogues: Design, synthesis, and potent VEGFR-2 inhibition with potential anti-renal cancer activity
Mahmoud, Huda K.,Farghaly, Thoraya A.,Abdulwahab, Hanan G.,Al-Qurashi, Nadia T.,Shaaban, Mohamed R.
, (2020)
Novel 2-indolinone thiazole hybrids were designed and synthesized as VEGFR-2 inhibitors based on sunitinib, an FDA-approved anticancer drug. The proposed structures of the prepared 2-indolinone thiazole hybrids were confirmed based on their spectral data and CHN analyses. The target compounds were screened in vitro for their anti-VEGFR-2 activity. All tested compounds exhibited a potent submicromolar inhibition of VEGFR-2 kinase with IC50 values ranging from 0.067 to 0.422 μM, relative to sunitinib reference drug (IC50 = 0.075 ± 0.002 μM). Compounds 5, 15a, 15b, 17, 19c displayed excellent VEGFR-2 inhibitory activity, comparable or nearly equipotent to sunitinib. Compound 13b stood out as the most potent against VEGFR-2 showing IC50 value of 0.067 ± 0.002 μM, lower than that of sunitinib. In addition, the most potent derivatives were assessed for their anticancer activity against two renal cancer cell lines. Compound 13b (IC50 = 3.9 ± 0.13 μM) was more potent than sunitinib (IC50 = 4.93 ± 0.16 μM) against CAKI-1 cell line. Moreover, thiazole 15b displayed excellent anticancer activity against CAKI-1 cell line (IC50 = 3.31 ± 0.11 μM), superior to that of sunitinib (IC50 = 4.93 ± 0.16 μM). Thiazole 15b was also equipotent to sunitinib (IC50 = 1.23 ± 0.04 μM) against A498 cell line. Besides, compound 15b revealed a safety profile much better than that of sunitinib against normal human renal cells. Furthermore, a docking study revealed a proper fitting of the most active compounds into the ATP binding site of VEGFR-2, rationalizing their potent anti-VEGFR-2 activity.
Investigations on Anticancer Potentials by DNA Binding and Cytotoxicity Studies for Newly Synthesized and Characterized Imidazolidine and Thiazolidine-Based Isatin Derivatives
Alkahtani, Saad,Anwar, Jamshed,Arshad, Nasima,Channar, Pervaiz Ali,Farooqi, Shahid Iqbal,Javaid, Memona,Javed, Aneela,Mir, Muhammad Ismail,Perveen, Fouzia,Saeed, Aamer
, (2022/01/11)
Imidazolidine and thiazolidine-based isatin derivatives (IST-01–04) were synthesized, characterized, and tested for their interactions with ds-DNA. Theoretical and experimental findings showed good compatibility and indicated compound–DNA binding by mixed
Direct catalytic synthesis of β-(C3)-substituted pyrroles: A complementary addition to the Paal-Knorr reaction
Pawar, Amol Prakash,Yadav, Jyothi,Mir, Nisar Ahmad,Iype, Eldhose,Rangan, Krishnan,Anthal, Sumati,Kant, Rajni,Kumar, Indresh
supporting information, p. 251 - 254 (2021/01/13)
The synthesis of β-(C3)-functionalized pyrroles is a challenging task and requires a multistep protocol. An operationally simple direct catalytic synthesis of β-substituted pyrroles has been developed. This one-pot multicomponent method combined aqueous succinaldehyde as 1,4-dicarbonyl, primary amines, and isatins to access hydroxyl-oxindole β-tethered pyrroles. Direct synthesis of the β-substituted free NH-pyrrole is the central intensity of this work. DFT-calculations and preliminary mechanism investigation support the possible reaction pathway. This journal is
