133841-08-4 Usage
Uses
Used in Pharmaceutical Industry:
7-METHOXY-3-INDAZOLECARBOXYLIC ACID is used as an intermediate in the synthesis of 7-Hydroxy Granisetron (H942675), a metabolite of Granisetron (G780000). Granisetron is a specific serotonin (5HT3) receptor antagonist, which is utilized as an antiemetic to treat nausea and vomiting following chemotherapy. The primary function of 7-METHOXY-3-INDAZOLECARBOXYLIC ACID is to reduce the activity of the vagus nerve, providing relief from the side effects of chemotherapy without affecting dopamine receptors or muscarinic receptors.
Check Digit Verification of cas no
The CAS Registry Mumber 133841-08-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,8,4 and 1 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 133841-08:
(8*1)+(7*3)+(6*3)+(5*8)+(4*4)+(3*1)+(2*0)+(1*8)=114
114 % 10 = 4
So 133841-08-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H8N2O3/c1-14-6-4-2-3-5-7(6)10-11-8(5)9(12)13/h2-4H,1H3,(H,10,11)(H,12,13)
133841-08-4Relevant articles and documents
High-affinity fluorescent ligands for the 5-HT3 receptor
Simonin, Jonathan,Vernekar, Sanjeev Kumar V.,Thompson, Andrew J.,Hothersall, J. Daniel,Connolly, Christopher N.,Lummis, Sarah C.R.,Lochner, Martin
, p. 1151 - 1155 (2012/03/26)
The synthesis, photophysical and biological characterization of a small library of fluorescent 5-HT3 receptor ligands is described. Several of these novel granisetron conjugates have high quantum yields and show high affinity for the human 5-HT3AR.
