133841-15-3

Basic information

• Product Name: 7-Hydroxygranisetron
• Synonyms: 7-HYDROXY GRANISETRON;7-Hydroxy-1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide;7-Hydroxy Granisetron HCl;7-Hydroxy Granisetron Labeled d3
• CAS NO: 133841-15-3
• Molecular Formula: C18H24N4O2
• Molecular Weight: 328.41
• Mol File: 133841-15-3.mol

Chemical Properties

• Melting Point: 225-230 °C (decomp)
• Boiling Point: 583.7±50.0 °C(Predicted)
• Appearance: /
• Density: 1.41
• PKA: 8.90±0.40(Predicted)
• CAS DataBase Reference: 7-Hydroxygranisetron(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Hydroxygranisetron(133841-15-3)
• EPA Substance Registry System: 7-Hydroxygranisetron(133841-15-3)

Safety Data

• Hazardous Substances Data: 133841-15-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
7-Hydroxygranisetron is used as an antiemetic agent for the prevention of nausea and vomiting associated with chemotherapy or radiation therapy. Its high potency and efficacy in blocking serotonin 5-HT3 receptors make it a superior alternative to traditional antiemetic medications, offering improved patient outcomes and reduced side effects.
Used in Oncology:
7-Hydroxygranisetron is used as a supportive care medication in oncology to alleviate the distressing symptoms of nausea and vomiting that patients often experience during cancer treatment. Its enhanced receptor-blocking capabilities contribute to better management of these symptoms, improving patients' quality of life and adherence to treatment regimens.
Used in Drug Development:
7-Hydroxygranisetron is utilized in the research and development of novel antiemetic medications. Its superior potency and efficacy in blocking serotonin receptors offer a foundation for the creation of new drugs that can provide more effective relief from nausea and vomiting, particularly in challenging clinical scenarios such as cancer treatment.

Upstream product

• 1210745-51-9 7-methoxy-1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide 
• 885278-98-8 ethyl 7-methoxy-1H-indazole-3-carboxylate 
• 133841-08-4 C₉H₈N₂O₃ 
• 868986-65-6 C₁₈H₂₄N₄O₂ 
• 217813-03-1 3-methoxy-2-(trimethylsilyl)phenyl-trifluoromethanesulfonate 

Relevant articles and documents

High-affinity fluorescent ligands for the 5-HT3 receptor

The synthesis, photophysical and biological characterization of a small library of fluorescent 5-HT3 receptor ligands is described. Several of these novel granisetron conjugates have high quantum yields and show high affinity for the human 5-HT3AR.

Toward biophysical probes for the 5-HT3 receptor: Structure-activity relationship study of granisetron derivatives

This report describes the synthesis and biological characterization of novel granisetron derivatives that are antagonists of the human serotonin (5-HT3A) receptor. Some of these substituted granisetron derivatives showed low nanomolar binding affinity and allowed the identification of positions on the granisetron core that might be used as attachment points for biophysical tags. A BODIPY fluorophore was appended to one such position and specifically bound to 5-HT3A receptors in mammalian cells.