1338441-77-2

Upstream product

• 3160-38-1 (E)-4-p-tolylbut-3-en-2-one 
• 292638-85-8 acrylic acid methyl ester 
• 252648-41-2 2-(Toluene-4-sulfonylamino)pent-4-enoic acid methyl ester 
• 1338441-54-5 (E)-methyl 2-(4-methylphenylsulfonamide)-6-oxohept-4-enoate 

Relevant academic research and scientific papers

Palladium(II)-Catalyzed Substituted Pyridine Synthesis from ?±,?-Unsaturated Oxime Ethers via a C-H Alkenylation/Aza-6?-Electrocyclization Approach

An efficient synthetic method for multisubstituted pyridines from β-aryl-substituted α,β-unsaturated oxime ethers and alkenes via Pd-catalyzed C-H activation has been developed. Systematic optimization of catalyst ligands revealed that sterically hindered

Synthesis of 2,4,6-trisubstituted pyridines via an olefin cross-metathesis/Heck-cyclisation-elimination sequence

Heck reactions were performed on α,β-unsaturated-δ- sulfonamido intermediates, derived from cross metathesis, to allow the instalment of substituents at the β position. Subsequent one-pot cyclisation/elimination provides an operationally simple, catalytic and convergent synthesis of 2,4,6-trisubstituted pyridines.