3160-38-1

Basic information

• Product Name: 4-(4-METHYLPHENYL)-3-BUTEN-2-ONE 97
• Synonyms: 4-(4-METHYLPHENYL)-3-BUTEN-2-ONE 97;1-(4-METHYLPHENYL)BUT-1-EN-3-ONE;4-(4-methylphenyl)but-3-en-2-one;1-(4-Methylphenyl)-1-butene-3-one;4-Methylstyrylmethyl ketone;Methyl 4-methylstyryl ketone;Methyl(4-methylstyryl) ketone;3-Buten-2-one, 4-(4-methylphenyl)-
• CAS NO: 3160-38-1
• Molecular Formula: C₁₁H₁₂O
• Molecular Weight: 160.21
• Product Categories: C11 to C12;Carbonyl Compounds;Ketones
• Mol File: 3160-38-1.mol
• Article Data: 125

Chemical Properties

• Melting Point: 29-33 °C(lit.)
• Boiling Point: 280.6°Cat760mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 0.999g/cm³
• Vapor Pressure: 0.00375mmHg at 25°C
• Refractive Index: 1.557
• CAS DataBase Reference: 4-(4-METHYLPHENYL)-3-BUTEN-2-ONE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-METHYLPHENYL)-3-BUTEN-2-ONE 97(3160-38-1)
• EPA Substance Registry System: 4-(4-METHYLPHENYL)-3-BUTEN-2-ONE 97(3160-38-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 3160-38-1(Hazardous Substances Data)

Usage

General Description

4-(p-Tolyl)-3-buten-2-one undergoes Reformatsky reaction with ethyl α-bromopropionate to yield β-hydroxy esters.

InChI:InChI=1/C11H12O/c1-9-3-6-11(7-4-9)8-5-10(2)12/h3-8H,1-2H3/b8-5+

Upstream product

• 589-18-4 4-Methylbenzyl alcohol 
• 152714-09-5 3-(4'-methylphenyl)cyclobutan-1-one 
• 624-31-7 4-tolyl iodide 
• 78-94-4 methyl vinyl ketone 
• 5720-05-8 4-methylphenylboronic acid 
• 135689-01-9 4-hydroxy-4-(4-methylphenyl)-butan-2-one 
• 32271-53-7 (E)-4-(p-tolyl)but-3-en-2-ol 
• 104-87-0 4-methyl-benzaldehyde 
• 13277-99-1 4-methylbenzaldehyde-α-d₁ 
• 909413-26-9 6-(tert-butyl)-12-(p-tolyl)-5,6,7,12-tetrahydrodibenzo[c,f][1,5]azastibocine 
• 7774-79-0 4-(4-methylphenyl)butan-2-one 
• 67-64-1 acetone 
• 123-42-2 4-Hydroxy-4-methyl-2-pentanone 
• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 

Downstream Products

• 39777-55-4 bis(4-methylstyryl)ketone 
• 93298-17-0 4,4-di-p-tolylbutan-2-one 
• 60234-84-6 (2E,4E)-3-Methyl-5-p-tolyl-penta-2,4-dienoic acid ethyl ester 
• 60234-93-7 (2Z,4E)-3-Methyl-5-p-tolyl-penta-2,4-dienoic acid ethyl ester 
• 130001-18-2 7-Methyl-1,3-diphenyl-2-thioxo-5-p-tolyl-1,2,3,5-tetrahydro-pyrano[2,3-d]pyrimidin-4-one 
• 130001-21-7 1,3-Bis-(2-methoxy-phenyl)-7-methyl-2-thioxo-5-p-tolyl-1,2,3,5-tetrahydro-pyrano[2,3-d]pyrimidin-4-one 
• 81467-90-5 (E)-4-(4'-Methylphenyl)-3-buten-2-on-dimethylhydrazon 
• 32271-53-7 (E)-4-(p-tolyl)but-3-en-2-ol 
• 61888-46-8 (3-Oxo-5-p-tolyl-cyclohex-1-enyl)-acetic acid methyl ester 
• 61888-40-2 3-Chloro-5-p-tolyl-cyclohex-2-enone 
• 251443-19-3 4,5-dihydro-3-methyl-5-(4-methylphenyl)-1-(4-methylsulphonylphenyl)-1H-pyrazole 
• 38080-85-2 (R)-4-hydroxy-3-[1-(4-methylphenyl)-3-oxo-butyl]-chromen-2-one 

Relevant articles and documents

Enantioselective one-pot two-step synthesis of hydrophobic allylic alcohols in aqueous medium through the combination of a Wittig reaction and an enzymatic ketone reduction

A one-pot two-step process for the enantioselective synthesis of hydrophobic allylic alcohols was developed, which comprises ketone formation by the Wittig reaction and their enzymatic in situ biotransformation into the desired target products. By means of this combined Wittig reaction and bioreduction, the allylic alcohols were prepared with conversions of up to 90 %, and with excellent enantioselectivities of >99 % ee. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

An efficient Pd@Pro-GO heterogeneous catalyst for the α, β-dehydrogenation of saturated aldehyde and ketones

An Efficient Pd@Pro-GO heterogeneous catalyst was developed that can promote the α, β-dehydrogenation of saturated aldehyde and ketones in the yield of 73% ? 92% at mild conditions without extra oxidants and additives. Pd@Pro-GO heterogeneous catalyst was synthesized via two steps: firstly, the Pro-GO was obtained by the esterification reaction between graphene oxide (GO) and N-(tert-Butoxycarbonyl)-L-proline (Boc-Pro-OH), followed by removing the protection group tert-Butoxycarbonyl (Boc), which endowed the proline-functionalized GO with both the lewis acid site (COOH) and the bronsted base site (NH), besides, the pyrrolidine of proline also can form imine with aldehydes to activate these substrates; Second, palladium was dispersed on the proline-functionalized GO (Pro-GO) to obtained heterogeneous catalyst Pd@Pro-GO. Mechanistic studies have shown that the Pd@Pro-GO-catalyzed α,β-dehydrogenation of saturated aldehyde and ketones was realized by an improved heterogeneously catalyzed Saegusa oxidation reaction. Based on the obove characteristics, the Pd@Pro-GO will be widely used in the transition metal catalytic field.

Piperlongumine derivative as well as preparation method and application thereof

The invention discloses a Piperlongumine derivative as well as a preparation method and application thereof. The Piperlongumine derivative has the following structure: the Piperlongumine derivative provided by the invention contains a plurality of Michael addition receptor units, and the novel structure improves the electrophilicity, so that the Piperlongumine derivative has good protein targetingpotential, and the Piperlongumine derivative has a good inhibition effect on thioredoxin reductase; in an antitumor bioactive in-vitro screening experiment, the derivative also has a certain inhibition effect on the growth of tumor cells, and meanwhile, the derivative has an effect of promoting the generation of active oxygen in A549 human lung cancer cells.