1338561-84-4Relevant academic research and scientific papers
Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform
Blackburn, Christopher,Barrett, Cynthia,Brunson, Mable,Chin, Janice,England, Dylan,Garcia, Kris,Gigstad, Kenneth,Gould, Alexandra,Gutierrez, Juan,Hoar, Kara,Rowland, R. Scott,Tsu, Christopher,Ringeling, John,Wager, Krista,Xu, He
, p. 5450 - 5454 (2014)
Acyl derivatives of 4-(aminomethyl)-N-hydroxybenzamide are potent sub-type selective HDAC6 inhibitors. Constrained heterocyclic analogs based on 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine show further enhanced HDAC6 selectivity and inhibitory activity in ce
SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF
-
Page/Page column 68, (2011/10/19)
This invention provides compounds of formula (I): wherein X1, X2, R1a, R1b, R1c, R1d, n, and G have values as described in the specification, useful as inhibitors of HDAC6. The invention al
