1338579-83-1

Upstream product

• 102900-58-3 17,20:20,21-bismethylenedioxy-11β-hydroxy-5β-pregnan-3-one 
• 1338579-71-7 [2,2,3β,4,4-d5]-17,20:20,21-bismethylenedioxy-3α,11β-dihydroxy-5β-pregnan 
• 1338579-78-4 [2,2,3β,4,4-d5]-3α-acetoxy-17,20:20,21-bismethylendioxy-11β-hydroxy-5β-pregnane 
• 1338579-81-9 C₂₅H₃₁⁽²⁾H₅O₇ 
• 1338579-82-0 [2,2,3β,4,4-d5]-3α-acetoxy-17α,21-dihydroxy-5β-pregnane-11,20-dione 
• 50-23-7 HYDROCORTISONE 
• 807-05-6 (8S,9S,10R,11S,13S,14S)-11-Hydroxy-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydrodispiro[cyclopenta[a]phenanthrene-17,4′-[1,3]dioxolane-5′,4″-[1,3]-dioxolan]-3(2H)-one 

Relevant academic research and scientific papers

Synthesis of 3- and 21-monosulfates of [2,2,3β,4,4-2H 5]-tetrahydrocorticosteroids in the 5β-series as internal standards for mass spectrometry

The 3- and 21-monosulfates of pentadeuterated 5β- tetrahydrocorticosteroides were synthesized, starting from cortisol and 11-deoxycotisol. The principal reactions used were (1) perdeuteration of the methylene groups adjacent to the 3-oxo group of 17,20:20,21-bismethylendioxy- 5β-3-ketosteroids with NaOD in CH3OD followed by stereoselective reduction with NaBD4, (2) sulfation of hydroxy groups with sulfur trioxide-trimethylamine complex, and (3) removal of the 17,20:20,21- bismethylendioxy group with hydrogen fluoride. The labeled compounds can be used as internal standards in liquid chromatography/mass spectrometry assays for clinical and biochemical studies.