1338594-65-2

Upstream product

• 1338594-60-7 C₃₃H₅₁N₃O₆Si 
• 202462-37-1 phenyl 2-azido-2-deoxy-1-thio-α/β-D-glucopyranoside 
• 183875-22-1 phenyl 2-azido-2-deoxy-3,4,6-tri-O-acetyl-1-thio-α/β-D-glucopyranoside 
• 164014-40-8 2,2-dimethyl-5-trifluoromethylsulfonyloxy-4H-(1,3)benzodioxin-4-one 
• 154714-19-9 5-hydroxy-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one 
• 303-07-1 2,6-Dihydroxybenzoic acid 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 1338594-64-1 2-azido-5-O-benzyl-2-deoxy-4-O-p-methoxybenzyl-1-O-pivaloyl-3-O-triisopropylsilyl-D-sorbitol 
• 1338594-63-0 2-azido-2-deoxy-4-O-p-methoxybenzyl-3-O-triisopropylsilyl-D-sorbitol 
• 378242-08-1 2,2-dimethyl-5-vinyl-4H-benzo[d][1,3]dioxin-4-one 

Downstream Products

• 1338594-58-3 C₃₇H₄₅N₃O₈ 
• 1338594-75-4 C₄₉H₆₃N₃O₈Si 

Relevant academic research and scientific papers

SOMATOSTATIN MIMETICS

Somatostatin is a tetradecapeptide that regulates, through binding to its receptors (SSTRs), a number of processes including the release of growth hormone and other pituitary hormones. Disclosed herein are a number of somatostatin mimetics that exhibit potential utility as therapeutic agents. Formula (I)

Synthesis of a benzomacrolactone-based somatostatin mimetic

The benzomacrolactone is a framework found in numerous natural products. The synthesis of an orthogonally functionalized benzomacrolactone from d-glucosamine and a salicylic acid derivative is described. This macrolactone was used for the synthesis of a somatostatin mimetic that has submicromolar affinity for the human somatostatin receptor 4 (hSSTR4).