13395-07-8

Basic information

• Product Name: Phenol, 2-chloro-6-(1,1-dimethylethyl)-4-methyl-
• CAS NO: 13395-07-8
• Molecular Formula: C11H15ClO
• Molecular Weight: 198.692
• Mol File: 13395-07-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Phenol, 2-chloro-6-(1,1-dimethylethyl)-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-chloro-6-(1,1-dimethylethyl)-4-methyl-(13395-07-8)
• EPA Substance Registry System: Phenol, 2-chloro-6-(1,1-dimethylethyl)-4-methyl-(13395-07-8)

Safety Data

• Hazardous Substances Data: 13395-07-8(Hazardous Substances Data)

Upstream product

• 2409-55-4 2-tert-Butyl-4-methylphenol 
• 25844-12-6 2-hydroxy-5-methyl-3-tert-butylbenzyl alcohol 
• 78074-81-4 5-t-butyl-7-methyl-1-oxaspiro<2,5>octa-5,7-dien-4-one 
• 10396-80-2 2,6-di-tert-butyl-4-hydroxy-4-methylcyclohexa-2,5-dienone 
• 128-37-0 2,6-di-tert-butyl-4-methyl-phenol 

Downstream Products

• 1131688-17-9 C₁₄H₁₉ClO 
• 65678-12-8 2-chloro-4-formyl-6-t-butylphenol 

Relevant articles and documents

Highly Selective Aromatic Chlorinations. Part 2. The Chlorination of Substituted Phenols, Anisoles, Anilines, and Related Compounds with N-Chloroamines in Acidic Solution

Phenols, anisoles, anilines, and related compounds are chlorinated in trifluoroacetic acid at room temperature by N-chlorodialkylamines and N-chlorotrialkylammonium salts.With monsubstituted compounds and their 2- and 3-substituted derivatives the reaction occurs efficiently and selectively at the 4-position.The reactivity of these substrates and the selectivity of their chlorinations are determined by electronic rather than steric effects of the substituent.Blocking the reaction with a substituent at the 4-position generally leads to only poor or moderate yields of the 2-chlorinated product.Evidence for radical and cation radical intermediates has been obtained in the reactions of some of the 4-substituted reactants and the mechanism of chlorination is discussed in the light of these findings.The reactions of selected substrates have been scaled up to give laboratory syntheses.

DIENONE-PHENOL CONVERSIONS OF 4-X-SUBSTITUTED 4-HYDROXY-2,6-DI-tert-BUTYLCYCLOHEXA-2,5-DIENONES IN ACID MEDIA

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