1339946-92-7

Upstream product

• 951288-55-4 (E)-benzyl 3-(3,4-bis(benzyloxy)phenyl)acrylate 
• 100-51-6 benzyl alcohol 
• 100-39-0 benzyl bromide 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 54429-62-8 (E)-3-(3,4-bis(benzyloxy)phenyl)acrylic acid 
• 1241892-06-7 benzyl (2R,3S)-2,3-dihydroxy-3-(3,4-dibenzyloxyphenyl)-propionate 
• 5396-89-4 benzyl acetoacetate 
• 5447-02-9 3,4-dibenzyloxybenzaldehyde 
• 1339947-25-9 (R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropionic acid benzyl ester 

Downstream Products

• 23028-17-3 danshensu 
• 1246887-09-1 C₂₃H₂₂O₅ 
• 1339947-17-9 C₁₃H₁₆O₆ 
• 1339947-16-8 C₁₃H₁₆O₆ 
• 1339947-15-7 C₁₂H₁₄O₆ 
• 1339947-02-2 C₃₁H₃₂N₂O₅ 
• 1339946-97-2 C₃₄H₃₄O₆ 
• 1339946-96-1 C₃₄H₃₄O₆ 

Relevant academic research and scientific papers

Danshensu derivativeS as well as preparation method and medical application thereof

The invention discloses Danshensu derivatives as well as a preparation method and medical application thereof. The derivatives have a general structure as shown in a general formula (I) shown in the specification, wherein R1 represents OH or OCH3; R2 represents H or Ac; and R3 represents a first structure, a second structure or a third structure shown in the specification. Compared with a raw material medicine, the derivatives synthesized by the invention have the advantages that the fat solubility is increased, so that the derivatives can penetrate through the blood-brain barrier (BBB), the medicine stability is greatly improved, and the curative effect is further improved. Therefore, the derivatives disclosed by the invention can be applied to preparation of drugs for preventing, treating, treating and/or reducing the cerebral infarction volume of a patient, improving the balance coordination ability of the patient and other diseases, and a new therapeutic drug is provided for preventing and treating cerebrovascular or cranial nerve diseases.

Efficient synthesis and physicochemical characterization of natural danshensu, its S isomer and intermediates thereof

The synthesis and molecular structure details of R- 3,4-dihydroxyphenyl lactic acid (danshensu) and related compounds, i.e. S isomer and the key intermediates have been described. Danshensu is an important water soluble phenolic acid of Salvia miltiorrhiza herb (danshen or red sag) with numerous applications in traditional Chinese medicine (TCM). Our synthetic approach was based on the Knoevenagel condensation of the protected 3,4-dihydroxybenzaldehyd and Meldrum acid derivative, followed by asymmetric Sharples dihydroxylation, reductive mono dehydroxylation and final deprotection. All compounds were characterized by various spectroscopic techniques: 1H-, 13C- magnetic resonance (NMR); Fourier-transformed infrared (FTIR); Raman, HR mass spectroscopy. For the determination of compound optical purities original HPLC methods were developed which allowed for the efficient resolution of danshensu R and S enantiomers as well as its intermediate enantiomers, using commercially available chiral stationary phases. Furthermore, in order to better understand danshensu specificity as a potential API in drug formulation, the physicochemical properties of the compounds were studied by thermal analysis, including differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA).