1339948-01-4Relevant articles and documents
Synthesis of enantiopure glycidol derivatives via a one-pot two-step enzymatic cascade
Liu, Yu-Chang,Liu, Yan,Wu, Zhong-Liu
, p. 2146 - 2152 (2015)
Styrene monooxygenase (SMO) can catalyze the kinetic resolution of secondary allylic alcohols to provide enantiopure glycidol derivatives. To overcome the low theoretical yield of kinetic resolution, we designed a one-pot two-step enzymatic cascade using prochiral α,β-unsaturated ketones as the substrates. An S-specific ketoreductase ChKRED03 was screened for the efficient bioreduction of the substrates to provide (S)-allylic alcohols, which underwent SMO-catalyzed epoxidation to achieve glycidol derivatives with contiguous stereogenic centers. Excellent enantioselectivity (ee > 99%) and diastereoselectivity (de > 99%) were achieved for the majority of the substrates, and product yields reached up to >99%. This journal is
Leoligin-inspired synthetic lignans with selectivity for cell-type and bioactivity relevant for cardiovascular disease
Linder, Thomas,Liu, Rongxia,Atanasov, Atanas G.,Li, Yuanfang,Geyrhofer, Sophie,Schwaiger, Stefan,Stuppner, Hermann,Schnürch, Michael,Dirsch, Verena M.,Mihovilovic, Marko D.
, p. 5815 - 5820 (2019/06/17)
Recently, a natural compound leoligin, a furan-type lignan, was discovered as an interesting hit compound with an anti-inflammatory pharmacological activity profile. We developed a modular and stereoselective approach for the synthesis of the edelweiss-de
