134-80-5
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Basic information
- Product Name: Amfepramone hydrochloride
- Synonyms: Moderatan;Tenapil;Diethylpropion Hydrochloride CIV (200 mg);Diethylcathinone (hydrochloride);1-Propanone,2-(diethylaMino)-1-phenyl-, hydrochloride (1:1);Diethylpropion hydrochloride solution ;DIETHYLPROPION HYDROCHLORIDE;2-(DIETHYLAMINO)PROPIOPHENONE HYDROCHLORIDE
- CAS NO:134-80-5
- Molecular Formula: C13H19NO*ClH
- Molecular Weight: 241.76
- EINECS: 205-156-5
- Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
- Mol File: 134-80-5.mol
- Article Data: 0
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Chemical Properties
- Melting Point: 180-1810C
- Boiling Point: 292°Cat760mmHg
- Flash Point: 9℃
- Appearance: /
- Density: 0.972g/cm3
- Vapor Pressure: 0.00189mmHg at 25°C
- Refractive Index: N/A
- Storage Temp.: Controlled Substance, -20°C Freezer
- Solubility: N/A
- CAS DataBase Reference: Amfepramone hydrochloride(CAS DataBase Reference)
- NIST Chemistry Reference: Amfepramone hydrochloride(134-80-5)
- EPA Substance Registry System: Amfepramone hydrochloride(134-80-5)
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Safety Data
- Hazard Codes: F,T
- Statements: 11-23/24/25-39/23/24/25-20/21/22
- Safety Statements: 7-16-36/37-45-36
- RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
- WGK Germany: 1
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 134-80-5(Hazardous Substances Data)
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134-80-5 Usage
Chemical Properties
Off-White SolidOriginator
Tenuate,Merrell National ,US,1959Uses
Controlled substance (stimulant). Anorexic.Definition
ChEBI: The hydrochloride salt of diethylpropion. A central stimulant and indirect-acting sympathomimetic, it is an appetite depressant and is used as an anoretic in the short term management of obesity.Manufacturing Process
1,145 g of α-bromopropiophenone and 850 g of diethylamine are combined under stirring and heated on a water bath to boiling. The precipitate is filtered off under suction and washed with benzol. The filtrate is shaken up with aqueous hydrogen chloride, the aqueous solution made alkaline and etherified. The solution freed of the ether is fractionated. The boiling point (6 mm) is 140°C and the yield 800 g. The base is dissolved in acetic ester and precipitated with isopropanolic hydrogen chloride. After suction filtration and washing with ether the yield is found to be 750 g (80%)and the melting point 168°C.Therapeutic Function
AnorexicGeneral Description
Because it has two large (relative to H or methyl) N-alkylsubstituents, diethylpropion hydrochloride, 1-phenyl-2-diethylaminopropan-1-one hydrochloride (Tenuate, Tepanil),has fewer sympathomimetic, cardiovascular, and CNSstimulatoryeffects than amphetamine. It is reportedly ananorexiant agent that can be used for the treatment of obesityin patients with hypertension and cardiovascular disease.According to the generalization long used for thisgroup of drugs, increasing N-alkyl size reduces central 1effects and increases β effects, even though the effects arelikely mediated principally by indirect NE release.Check Digit Verification of cas no
The CAS Registry Mumber 134-80-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 4 respectively; the second part has 2 digits, 8 and 0 respectively.Calculate Digit Verification of CAS Registry Number 134-80:
(5*1)+(4*3)+(3*4)+(2*8)+(1*0)=45
45 % 10 = 5
So 134-80-5 is a valid CAS Registry Number.
InChI:InChI=1/C13H19NO.ClH/c1-4-14(5-2)11(3)13(15)12-9-7-6-8-10-12;/h6-11H,4-5H2,1-3H3;1H