134-91-8

Usage

Uses

Used in Pharmaceutical Synthesis:
BIS(4-DIETHYLAMINOPHENYL)METHANOL is used as a starting material for the production of various active pharmaceutical ingredients, contributing to the development of new medications and therapeutic agents.
Used in Organic Chemical Reactions:
As a reagent, BIS(4-DIETHYLAMINOPHENYL)METHANOL is employed in a range of organic chemical reactions, facilitating the synthesis of complex organic molecules and compounds.
Used in Asymmetric Catalysis:
BIS(4-DIETHYLAMINOPHENYL)METHANOL is utilized as a chiral ligand in asymmetric catalysis, playing a crucial role in the selective formation of enantiomers, which is essential in the production of enantiomerically pure compounds for pharmaceutical applications.
Used in Medicinal Chemistry and Drug Development:
BIS(4-DIETHYLAMINOPHENYL)METHANOL is applied in the field of medicinal chemistry and drug development, where its chiral properties are harnessed to create novel and effective drugs with improved pharmacological profiles.
Used in the Preparation of Chiral Compounds:
BIS(4-DIETHYLAMINOPHENYL)METHANOL is also used in the preparation of other chiral compounds, which are vital in various industrial applications, including the synthesis of specialty chemicals and materials with unique properties.

InChI:InChI=1/C21H30N2O/c1-5-22(6-2)19-13-9-17(10-14-19)21(24)18-11-15-20(16-12-18)23(7-3)8-4/h9-16,21,24H,5-8H2,1-4H3

Upstream product

• 90-93-7 4,4'-bis(diethylamino)benzophenone 
• 135-91-1 4-(4-(diethylamino)benzyl)-N,N-diethylbenzenamine 
• 64-19-7 acetic acid 
• 2052-06-4 4-bromo-N,N-diethylaniline 
• 120-21-8 4-Diethylaminobenzaldehyde 

Downstream Products

• 107572-88-3 4-(4,4'-bis-diethylamino-α-hydroxy-benzhydryl)-naphthalene-2,7-disulfonic acid 
• 60813-13-0 (4-diethylamino-2-methyl-phenyl)-bis-(4-diethylamino-phenyl)-methane 
• 93641-91-9 4-(4,4'-bis-diethylamino-benzhydryl)-phenol 
• 145494-12-8 C₃₃H₃₉N₅ 
• 145494-17-3 4,4'-bis(diethylamino)benzhydylanilin 
• 1220284-25-2 C₂₇H₃₈N₂O 

Relevant academic research and scientific papers

Photo-induced phosphorus radical involved semipinacol rearrangement reaction: Highly synthesis of γ-oxo-phosphonates

Hydroxyphosphoric acids display the unique biological activities, and they have some attractive prospects as clinical drug moleculars. Herein, a new approach for the synthesis of γ-oxo-phosphonates (the precursor of hydroxyphosphoric acid) has been established through the semipinacol rearrangement tactic involved the photo-induced phosphorus radical process. Most important, this transformation is avoid of the external oxidants, and occurs very well under the sunlight irradiation, meanwhile the γ-oxo-phosphonate was easily derivatized to obtain γ-hydroxyphosphoric acid, thus highlights the synthesis value of this method.

With double-to the body structure of the organic second-order non-linear optical chromophore and synthetic method and use (by machine translation)

The present invention has offered a kind of double-to the body structure of the organic second-order non-linear optical chromophore, the with double to the body structure of the organic second-order non-linear optical chromophore has the following structure: Wherein R1 Is methyl or trifluoromethyl; R2 Is alkyl or phenyl. The invention used with a two-to the body structure of the electron donor, conjugated π electronic bridge and electronic receptor are combined together in the molecule after the electronic transmission capacity, can improve the electro-optic coefficient. In addition, the synthesized chromophores with double to the body structure, can effectively reduce the intermolecular interaction force. The said organic second order non-linear optical chromophore with amorphous polycarbonate doped for synthetic polymer film, the polymer film can be used as a synthetic light signal modulation material. (by machine translation)

Synthesis and optical nonlinear property of Y-type chromophores based on double-donor structures with excellent electro-optic activity

New Y-type chromophores FTC-yh1 and FTC-yh2 containing bis(N,N-diethyl) aniline as a novel electron-donor, thiophene as a π-conjugated bridge and tricyanofuran (TCF) as an acceptor have been synthesized and systematically investigated in this paper. Density functional theory (DFT) was used to calculate the HOMO-LUMO energy gaps and first-order hyperpolarizability (β) of these chromophores. These chromophores showed better thermal stability with their decomposition temperatures all above 240 °C. Most importantly, the high molecular hyperpolarizability of these chromophores can be effectively translated into large electro-optic (EO) coefficients (r33) in poled polymers. The doped film-A containing 25 wt% chromophore FTC-yh1 displayed a value of 149 pm V-1 at 1310 nm, and the doped film-B containing FTC-yh2 showed a value of 143 pm V-1 at the concentration of 25 wt%. These values are almost four times higher than the EO activity of usually reported traditional single (N,N-diethyl)aniline nonlinear optical (NLO) chromophores FTC. High r33 values indicated that the double donors of the bis(N,N-diethyl)aniline unit can efficiently improve the electron-donating ability and reduce intermolecular electrostatic interactions, thus enhancing the macroscopic EO activity. These properties, together with the good solubility, suggest the potential use of the new chromophores as advanced material devices.

Asymmetric SN 1 α-Alkylation of cyclic ketones catalyzed by functionalized chiral ionic liquid (FCIL) organocatalysts

Ionic liquid works better: The first intermolecular asymmetric α-alkylation of cyclic ketones was realized by using functionalized chiral ionic liquids as catalysts. The reaction proceeded with good to excellent yields and high ee. Highly stereoselective desymmetrization of 4-substituted cyclohexanones with >99:1 d.r. and up to 87 % ee were achieved by using this protocol. (Chemical Equation Representation).