135-91-1

Basic information

• Product Name: N1,N1-DIETHYL-4-[4-(DIETHYLAMINO)BENZYL]ANILINE
• Synonyms: N1,N1-DIETHYL-4-[4-(DIETHYLAMINO)BENZYL]ANILINE;4,4'-methylenebis[N,N-diethylaniline];4-(4-diethylamino)benzyl)-N,N-diethylbenzenamine;4,4'-Methylenebis(N,N-diethylbenzenamine);Bis(4-diethylaminophenyl)methane;4-[[4-(diethylamino)phenyl]methyl]-N,N-diethylaniline
• CAS NO: 135-91-1
• Molecular Formula: C₂₁H₃₀N₂
• Molecular Weight: 310.48
• EINECS: 205-224-4
• Mol File: 135-91-1.mol
• Article Data: 11

Chemical Properties

• Melting Point: 43.5-44 °C
• Boiling Point: 443.5 °C at 760 mmHg
• Flash Point: 198.3 °C
• Appearance: /
• Density: 0.998g/cm³
• Vapor Pressure: 4.61E-08mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• PKA: 7.14±0.32(Predicted)
• CAS DataBase Reference: N1,N1-DIETHYL-4-[4-(DIETHYLAMINO)BENZYL]ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: N1,N1-DIETHYL-4-[4-(DIETHYLAMINO)BENZYL]ANILINE(135-91-1)
• EPA Substance Registry System: N1,N1-DIETHYL-4-[4-(DIETHYLAMINO)BENZYL]ANILINE(135-91-1)

Safety Data

• Hazardous Substances Data: 135-91-1(Hazardous Substances Data)

Usage

General Description

N1,N1-Diethyl-4-[4-(diethylamino)benzyl]aniline is a chemical compound that is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. It is a substituted benzylamine derivative with a diethylamino group and an additional ethyl group attached to the nitrogen atoms. This chemical is commonly used as a building block in the production of dyes, optical brighteners, and other organic compounds. It is also used as a reagent in organic synthesis and as a catalyst in various chemical reactions. Additionally, this compound has been studied for its potential pharmacological properties and has shown some promise in the development of new medicinal compounds.

InChI:InChI=1/C21H30N2/c1-5-22(6-2)20-13-9-18(10-14-20)17-19-11-15-21(16-12-19)23(7-3)8-4/h9-16H,5-8,17H2,1-4H3

Upstream product

• 90-93-7 4,4'-bis(diethylamino)benzophenone 
• 25642-33-5 4,4'-bis-diethylamino-thiobenzophenone 
• 1634-04-4 tert-butyl methyl ether 
• 91-66-7 N,N-diethylaniline 
• 67-68-5 dimethyl sulfoxide 
• 110-18-9 N,N,N,N,-tetramethylethylenediamine 
• 1066-26-8 sodium acetylide 
• 50-00-0 formaldehyd 
• 629-01-6 n-octanamide 
• 7647-01-0 hydrogenchloride 
• 71893-15-7 C₄H₇ClHgO 
• 5293-94-7 bis(chloromethyl)mercury 
• 129075-92-9 (4-Benzotriazol-1-ylmethyl-phenyl)-diethyl-amine 
• 75-09-2 dichloromethane 

Downstream Products

• 2390-59-2 ethyl violet 
• 519-73-3 triphenylmethane 
• 90-93-7 4,4'-bis(diethylamino)benzophenone 
• 2390-60-5 Victoria Pure Ink Blue BO 
• 945-81-3 N-nitroso N-ethyl-N-(4-nitroaniline) 
• 2216-15-1 1-diethylamino-4-nitrobenzene 
• 134-91-8 4,4'-bis(N,N-diethylamino)benzhydrol 
• 859330-22-6 bis-(4-diethylamino-2-nitro-phenyl)-methane 
• 97423-02-4 bis-(4-diethylamino-cyclohexyl)-methane 

Relevant articles and documents

Selectfluor facilitated bridging of indoles to bis(indolyl)methanes using methyl: Tert -butyl ether as a new methylene precursor

A novel, green and efficient method is developed for the synthesis of methylene bridged bis(indolyl)methanes in good to excellent yields. The reaction employs methyl tert-butyl ether (MTBE) as the methylene source and selectfluor as an oxidizing agent. The scope and versatility of the methods have been successfully demonstrated with 48 examples. The metal-free transformation process is suitable for scale-up production. A selectfluor-promoted oxidative reaction mechanism is proposed based on the results of the experimental studies. This journal is

Highly regioselective para-methylthiolation/bridging methylenation of arylamines promoted by NH4I

Aryl methyl thioethers and methylene-bridged arylamines were synthesized via highly regioselective para-methylthiolation/bridging methylenation of arylamines using DMSO as the methylthio or methylene source in the presence of NH4I under metal-free conditions. For the substrates with both electron-donating and electron-withdrawing substituents, the reaction proceeded smoothly and gave moderate to good yields.

Cu(ii)-catalyzed C-H (SP3) oxidation and C-N cleavage: Base-switched methylenation and formylation using tetramethylethylenediamine as a carbon source

Base-switched methylenation and formylation using tetramethylethylenediamine (TMEDA) as a carbon source have been achieved under mild conditions, catalyzed by CuCl2, with atmospheric oxygen as oxidant. Bisindolylmethanes, diphenylmethanes and 3-formylindoles were synthesized with excellent regioselectivity and good yield.