134018-89-6Relevant academic research and scientific papers
Lipase-catalyzed resolution of ibuprofen
Henke, Erik,Schuster, Sascha,Yang, Hong,Bornscheuer, Uwe T.
, p. 633 - 638 (2000)
The resolution of ibuprofen by transesterification of its corresponding vinylester using lipase B from Candida antarctica is described. Compared to transesterification or hydrolysis of the ibuprofen ethyl ester (E2, 28-48h), the reaction with vinylesters occurred significantly faster (1.5-5h) and with considerably higher enantioselectivity (E=8-39).
Process for the resolution of esters of arylalkylcarboxylic acids
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, (2008/06/13)
The invention relates to a process for the resolution of esters of arylalkylcarboxylic acids of the general formula which comprises reacting compounds of the general formula I with an alcohol of the general formula R6—OH in the presence of a li
Vinyl 2-aryl-propionates
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, (2008/06/13)
In the enzymatic stereoselective ester cleavages of 2-arylpropionate, the reaction rate of the hydrolyzing enzymes can be drastically increased if the vinyl ester of the 2-arylpropionate is employed as the substrate.
