1340416-25-2Relevant academic research and scientific papers
Oxidative 3,3,3-trifluoropropylation of arylaldehydes
Ikeda, Akari,Omote, Masaaki,Nomura, Shiho,Tanaka, Miyuu,Tarui, Atsushi,Sato, Kazuyuki,Ando, Akira
, p. 2417 - 2421 (2013)
A reaction between (E)-trimethyl(3,3,3-trifluoroprop-1-en-1-yl)silane (1) and arylaldehydes 2 was triggered by fluoride anions to afford aryl 3,3,3-trifluoropropyl ketones 3 in moderate to good yield. A mechanistic study of this reaction indicated that it occurred via an allyl alkoxide (4). A subsequent 1,3-proton shift of the benzylic proton of 4 forms 3. This reaction involves oxidative 3,3,3-trifluoropropylation of an arylaldehyde to afford 4,4,4-trifluoro-1-arylbutan-1-one.
Preparation method of 1-aryl-4,4,4-trifluoro-1-butanone compound
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Paragraph 0047; 0054-0056, (2018/11/10)
The invention relates to a preparation method of a 1-aryl-4,4,4-trifluoro-1-butanone compound and belongs to the field of compound preparation. The preparation method is characterized by comprising the following steps of by taking trifluoromethyl-substituted enol sulfonate as a compound shown in a general formula II as a raw material, synthesizing 1-aryl-4,4,4-trifluoro-1-butanone as a compound shown in a general formula I: the formula l is shown in the description. The method provided by the invention provides a method which is convenient and is low in cost for synthesis of the 1-aryl-4,4,4-trifluoro-1-butanone compound and avoids using an expensive metal catalyst reagent.
Synthesis of β-CF 3 Ketones through Copper/Silver Cocatalyzed Oxidative Coupling of Enol Acetates with ICH 2 CF 3
Xiong, Yi,Chen, De,Zeng, Sheng,Cheng, Chaozhihui,Wang, Pengjie,Deng, Wei,Xiang, Jiannan,Yi, Niannian
supporting information, p. 2279 - 2282 (2018/10/20)
A simple method for the synthesis of β-CF 3 ketones through copper/silver cocatalyzed oxidative coupling of enol acetates with ICH 2 CF 3 has been developed. Enol acetates were chosen as the source of carbonyl group, giving the β-CF 3 ketones in moderate yields. Control experiments imply that a radical process maybe involved in this reaction.
Copper/Silver Cocatalyzed Oxidative Coupling of Vinylarenes with ICH2CF3 or ICH2CHF2 Leading to β-CF3/CHF2-Substituted Ketones
Yi, Niannian,Zhang, Hao,Xu, Chonghui,Deng, Wei,Wang, Ruijia,Peng, Dongming,Zeng, Zebing,Xiang, Jiannan
supporting information, p. 1780 - 1783 (2016/05/19)
A novel copper/silver cocatalyzed oxidative coupling of vinylarenes with ICH2CF3 or ICH2CHF2 through a radical process has been developed. The transformation provides an attractive approach to β-CF3/CHF2-substituted ketones, with the advantages of easily available starting materials and operational simplicity.
