1340544-08-2Relevant academic research and scientific papers
Chemodivergent synthesis of 7-aryl/alkyl-6-hydroxy-1,4-oxazepan-5-ones and 2-[aryl/alkyl(hydroxy)methyl]morpholin-3-ones from a common epoxyamide precursor
Aparicio, David M.,Teran, Joel L.,Roa, Luis F.,Gnecco, Dino,Juarez, Jorge R.,Orea, Maria L.,Mendoza, Angel,Flores-Alamo, Marcos,Micouin, Laurent
, p. 2310 - 2320 (2011/09/16)
We present here a regiospecific synthesis of 7-alkyl- or 7-aryl-6-hydroxy-1,4-oxazepan-5-ones and 2-[aryl(hydroxy)methyl]- or 2-(1-hydroxyalkyl)morpholin-3-ones from a diastereomeric mixture of trans-3-alkyl- or -3-aryl-N-(2-hydroxyethyl)-N-(1-phenylethyl)oxirane-2- carboxamides. This chemodivergent synthesis is easily controlled by an appropriate choice of cyclization reaction conditions. Georg Thieme Verlag Stuttgart - New York.
