6623-43-4

Basic information

• Product Name: 2-(1-phenylethylamino)ethanol
• Synonyms: Ethanol,2-[(a-methylbenzyl)amino]-(6CI,7CI,8CI); NSC 35362; NSC 54968
• CAS NO: 6623-43-4
• Molecular Formula: C₁₀H₁₅NO
• Molecular Weight: 165.24
• EINECS: 202-160-9
• Mol File: 6623-43-4.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 285.7°C at 760 mmHg
• Flash Point: 114.4°C
• Appearance: /
• Density: 1.017g/cm³
• Vapor Pressure: 0.00129mmHg at 25°C
• Refractive Index: 1.53
• PKA: 14.74±0.10(Predicted)
• CAS DataBase Reference: 2-(1-phenylethylamino)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-phenylethylamino)ethanol(6623-43-4)
• EPA Substance Registry System: 2-(1-phenylethylamino)ethanol(6623-43-4)

Safety Data

• Hazardous Substances Data: 6623-43-4(Hazardous Substances Data)

Usage

General Description

2-(1-phenylethylamino)ethanol is a chemical compound consisting of a phenylethylamine group attached to a hydroxyl group. It is commonly used as a precursor in the synthesis of various pharmaceutical drugs, such as sympathomimetic amines and adrenergic agonists. 2-(1-phenylethylamino)ethanol exhibits adrenergic properties, acting as a stimulant on the sympathetic nervous system. It is also used in the production of surfactants and emulsifiers due to its amphiphilic nature. Additionally, 2-(1-phenylethylamino)ethanol is utilized in the formulation of personal care products, including perfumes and fragrances. Due to its potential stimulant effects, this compound should be handled with care and used in accordance with appropriate safety protocols.

InChI:InChI=1/C10H15NO/c1-9(11-7-8-12)10-5-3-2-4-6-10/h2-6,9,11-12H,7-8H2,1H3

Upstream product

• 141-43-5 ethanolamine 
• 98-86-2 acetophenone 
• 693-06-1 (2-hydroxyethyl)-formamide 
• 64-17-5 ethanol 
• 618-36-0 rac-methylbenzylamine 
• 540-51-2 2-bromoethanol 
• 65687-97-0 2-methyl-2-phenyloxazolidine 
• 164219-31-2 ethyl (S)-2-oxo-2-((1-phenylethyl)amino)acetate 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 107-07-3 2-chloro-ethanol 
• 164219-32-3 (S)-2-oxo-2-((1-phenylethyl)amino)acetic acid 
• 75-21-8 oxirane 
• 2627-86-3 (-)-α-methylbenzylamine 

Downstream Products

• 102881-92-5 N-(2-hydroxy-ethyl)-N-(1-phenyl-ethyl)-β-alanine nitrile 
• 103206-32-2 (1-phenyl-ethyl)-(2-vinyloxy-ethyl)-carbamic acid methyl ester 
• 6948-01-2 N-formyl-α-methylbenzylamine 
• 618-36-0 rac-methylbenzylamine 
• 817168-33-5 4-((S)-1-Phenyl-ethyl)-morpholine-2,3-dione 
• 869800-24-8 [1(1S),2S]-1-(1-phenyl-ethyl)-azetidine-2-carbonitrile 
• 869800-25-9 [1(1S),2R]-1-(1-phenyl-ethyl)-azetidine-2-carbonitrile 
• 869800-23-7 (S)-2-[(2-chloro-ethyl)-(1-phenyl-ethyl)-amino]-acetonitrile 
• 249734-37-0 benzyl [1(1S,2R)]-1-(1-phenyl-ethyl)-azetidine-2-carboxylate 
• 247051-66-7 benzyl [1(1S,2S)]-1-(1-phenyl-ethyl)-azetidine-2-carboxylate 
• 869800-29-3 benzyl (S)-[(2-chloro-ethyl)-(1-phenyl-ethyl)-amino]ethanoate 
• 869800-26-0 (S)-1-((S)-1-Phenyl-ethyl)-azetidine-2-carboxylic acid; hydrochloride 
• 869800-26-0 (R)-1-((S)-1-Phenyl-ethyl)-azetidine-2-carboxylic acid; hydrochloride 
• 1357081-31-2 C₁₂H₁₅NO₂ 

Relevant articles and documents

Synthesis of pyrrole N-derivatives from oxazolidines

Transformations of oxazolidine derivatives synthesized from industrially produced amino alcohols, aldehydes, and ketones under basic or acidic catalysis lead to the formation of N-alkyl- and N-(hydroxyalkyl)-substituted pyrroles in 19-81% yields.

Chemodivergent synthesis of 7-aryl/alkyl-6-hydroxy-1,4-oxazepan-5-ones and 2-[aryl/alkyl(hydroxy)methyl]morpholin-3-ones from a common epoxyamide precursor

We present here a regiospecific synthesis of 7-alkyl- or 7-aryl-6-hydroxy-1,4-oxazepan-5-ones and 2-[aryl(hydroxy)methyl]- or 2-(1-hydroxyalkyl)morpholin-3-ones from a diastereomeric mixture of trans-3-alkyl- or -3-aryl-N-(2-hydroxyethyl)-N-(1-phenylethyl)oxirane-2- carboxamides. This chemodivergent synthesis is easily controlled by an appropriate choice of cyclization reaction conditions. Georg Thieme Verlag Stuttgart - New York.

Practical asymmetric preparation of azetidine-2-carboxylic acid

Facile and straightforward syntheses of both enantiomers of azetidine-2-carboxylic acid are described. The syntheses depart from inexpensive chemicals and allow for the production, in five to six steps, of practical quantities of each enantiomer. Synthetic highlights include the construction of the azetidine ring using an intramolecular alkylation and the use of optically active α-methylbenzylamine as chiral auxiliary.