134106-66-4

Basic information

• Product Name: methyl 8-(chloromethyl)-4-hydroxy-2-methyl-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3,6,7,8-tetrahydropyrrolo[3,2-e]indole-1-carboxylate
• Synonyms: Benzo(1,2-b:4,3-b')dipyrrole-1-carboxylic acid, 3,6,7,8-tetrahydro-8-(chloromethyl)-4-hydroxy-2-methyl-6-((5,6,7-trimethoxy-1H-indol-2-yl)carbonyl)-, methyl ester
• CAS NO: 134106-66-4
• Molecular Formula: C₂₆H₂₆ClN₃O₇
• Molecular Weight: 527.9535
• Mol File: 134106-66-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 765.2°C at 760 mmHg
• Flash Point: 416.6°C
• Density: 1.432g/cm³
• Vapor Pressure: 2.97E-24mmHg at 25°C
• Refractive Index: 1.682
• CAS DataBase Reference: methyl 8-(chloromethyl)-4-hydroxy-2-methyl-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3,6,7,8-tetrahydropyrrolo[3,2-e]indole-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 8-(chloromethyl)-4-hydroxy-2-methyl-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3,6,7,8-tetrahydropyrrolo[3,2-e]indole-1-carboxylate(134106-66-4)
• EPA Substance Registry System: methyl 8-(chloromethyl)-4-hydroxy-2-methyl-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3,6,7,8-tetrahydropyrrolo[3,2-e]indole-1-carboxylate(134106-66-4)

Safety Data

• Hazardous Substances Data: 134106-66-4(Hazardous Substances Data)

Upstream product

• 156295-30-6 (S)-3-Acetoxymethyl-6-benzyloxy-5-((E)-2-methoxycarbonyl-1-methyl-vinylamino)-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester 
• 156295-31-7 (S)-8-Acetoxymethyl-4-benzyloxy-2-methyl-7,8-dihydro-3H-pyrrolo[3,2-e]indole-1,6-dicarboxylic acid 6-tert-butyl ester 1-methyl ester 
• 156295-32-8 (S)-4-Benzyloxy-8-hydroxymethyl-2-methyl-7,8-dihydro-3H-pyrrolo[3,2-e]indole-1,6-dicarboxylic acid 6-tert-butyl ester 1-methyl ester 
• 156295-33-9 (S)-4-Benzyloxy-8-chloromethyl-2-methyl-7,8-dihydro-3H-pyrrolo[3,2-e]indole-1,6-dicarboxylic acid 6-tert-butyl ester 1-methyl ester 
• 179693-97-1 (S)-8-Chloromethyl-4-hydroxy-2-methyl-7,8-dihydro-3H-pyrrolo[3,2-e]indole-1,6-dicarboxylic acid 6-tert-butyl ester 1-methyl ester 
• 105-45-3 acetoacetic acid methyl ester 
• 128781-07-7 5,6,7-trimethoxy-1H-indole-2-carboxylic acid 

Relevant articles and documents

Novel syntheses of optically active CC-1065, U-73,975(adozelesin), U-80,244(carzelesin), U-77,779(bizelesin), KW-2189, and DU-86

The title syntheses were achieved by the method featuring oxidative cyclization of the enamino esters [(S)-13 and (S)-24] derived from the 5-aminoindoline [(5)-12], acylation with various structural types of indole-2-carboxylic acids, and formation of cyclopropapyrroloindole moieties.