1341207-20-2

Upstream product

• 1341207-17-7 3-(4-chlorobenzoyl)amino-2-hydroxymethylindole 
• 850929-38-3 ethyl 3-(4-chlorobenzoyl)aminoindole-2-carboxylate 
• 87223-77-6 ethyl 3-amino-1H-indole-2-carboxylate 
• 122-01-0 4-chloro-benzoyl chloride 

Relevant academic research and scientific papers

One-step ring-closure procedure for 4,5-dihydro-1,3-thiazino[5,4-b]indole derivatives with Lawesson's reagent. the fifth dihydro-1,3-thiazino[b]indole isomer

We report a convenient approach for the synthesis of a new ring system: 4,5-dihydro-1,3-thiazino[5,4-b]indoles. The procedure involves the use of Lawesson's reagent in the presence of silica to achieve the one-step ring-closure reactions of 2-benzoylamino-3-hydroxymethylindole intermediates to furnish 4,5-dihydro-2-aryl-1,3-thiazino[5,4-b]indoles. 2-Phenylimino-1,3- thiazino[5,4-b]indoles were obtained via the corresponding 3-phenylthiourea-2- carboxylic acid ester derivatives by chemoselective reduction of the ester group, followed by ring closure under acidic conditions. The structures of the novel products were elucidated by IR, 1H-NMR, and 13C-NMR spectroscopy, including 2D-HMQC, 2D-HMBC, and DEPT measurements.