13414-56-7

Usage

Uses

Used in Organic Synthesis:
2,3-Dihydrobenzo[b]furan-7-ylamine is used as a building block in organic synthesis for the preparation of various biologically active molecules and heterocyclic compounds. Its unique structure allows for the formation of diverse chemical entities with potential applications in different industries.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2,3-Dihydrobenzo[b]furan-7-ylamine is used as a key intermediate in the development of new drugs. Its ability to form heterocyclic compounds makes it a valuable component in the synthesis of potential therapeutic agents.
Used in Drug Discovery:
2,3-Dihydrobenzo[b]furan-7-ylamine is employed in drug discovery for its potential therapeutic applications. Its unique chemical properties and ability to form various biologically active molecules make it a promising candidate for the development of new pharmaceuticals.
Overall, 2,3-Dihydrobenzo[b]furan-7-ylamine is a versatile and important chemical compound with a wide range of applications in organic synthesis, pharmaceutical research, and drug discovery. Its unique structure and potential to form diverse chemical entities contribute to its significance in the field of organic chemistry and pharmaceuticals.

Upstream product

• 496-16-2 2.3-dihydrobenzofuran 
• 35700-40-4 2,3-dihydrobenzofuran-7-carboxylic acid 

Relevant academic research and scientific papers

Synthesis and SAR of highly potent dual 5-HT1A and 5-HT 1B antagonists as potential antidepressant drugs

Novel 5-HT1 autoreceptor ligands based on the N-4-aryl-piperazinyl-N′-ethyl-5,6,7,8-tetrahydropyrido[4′, 3′:4,5]thieno[2,3-d]pyrimidin-4(3H)-one core are described. Aiming at antidepressants with a novel mode of action our objective was to identify potent antagonists showing balanced affinities and high selectivity for the 5-HT 1A and 5-HT1B receptors. Strategies for the development of dual 5-HT1A and 5-HT1B antagonists based on 1 and 2 as leads and the corresponding results are discussed. Isoquinoline analogue 33 displayed high affinity and an antagonistic mode of action for the 5-HT 1A and the 5-HT1B receptors and was characterized further with respect to selectivity, electrically stimulated [3H]5-HT release and in vivo efficacy.

Fe-Catalyzed Amination of (Hetero)Arenes with a Redox-Active Aminating Reagent under Mild Conditions

A novel and efficient Fe-catalyzed direct C?H amination (NH2) of arenes is reported using a new redox-active aminating reagent. The reaction is simple, and can be performed under air, mild, and redox-neutral conditions. This protocol has a broad substrate scope and could be used in the late-stage modification of bioactive compounds. Mechanistic studies demonstrate that a radical pathway could be involved in this transformation.

2, 4- DI (PHENYLAMINO) PYRIMIDINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS

Novel pyrimidine derivatives of formula (I), to processes for their production, their use as pharmaceuticals in the treatment of neoplastic diseases, inflammatory and immune system disorders and to pharmaceutical compositions comprising them.

Tricyclic furo-quinazolinones

Anti-inflammatories and analgesics of the formula SPC1 Wherein X y is --OCH2 CH2 -- or --CH2 CH2 O--, R is lower alkyl, allyl or cycloalkylalkyl and R' is phenyl or phenyl monosubstituted by halo, alkyl, alkoxy