13415-07-1Relevant academic research and scientific papers
Convenient preparation of tacrine derivatives by the reduction of 9-aminoacridines with nickel-aluminum alloy
Kamata, Kichinosuke,Tominaga, Yoh-Ichi,Tori-I, Akiyoshi,Thiemann, Thies,Takahashi, Kazufumi,Mataka, Shuntaro
, p. 1683 - 1688 (2007/10/03)
9-Amino-1,2,3,4-tetrahydro- and 9-amino-1,2,3,4,5,6,7,8-octahydro-acridine derivatives (2 and 3) were conveniently prepared in the reduction of the corresponding 2-substituted 9-aminoacridines (1a-f) with nickel-aluminum alloy under basic conditions. The reduction is dependent upon the nature of the substituent in the 2-position of the starting 9-aminoacridines.
Selective Hydrogenation of 9-Aminoacridine over Supported Noble Metal Catalysts
Sakanishi, Kinya,Mochida, Isao,Okazaki, Hiroshi,Soeda, Mahito
, p. 319 - 322 (2007/10/02)
The selective hydrogenation of 9-aminoacridine (1) into 1,2,3,4-tetrahydro-derivative (2) was searched using noble metal catalysts (Pd, Rh, Pt, and Ru) at around 80 deg C and 60 atm of H2.The Pd/Al2O3 catalyst was found most selective to produce 2 in a higher yield of 60 percent at a conversion of 97 percent.The hydrogenation pathway of 1 is discussed in comparison with that of acridine.
